Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea
A rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020...
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doaj-35aa6f22d7244bd9b0d82606316b3ee32020-11-25T03:53:25ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0191959195910.3390/jcm9061959Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South KoreaMin Hyuk Choi0Hyunmin Ahn1Han Seok Ryu2Byung-Jun Kim3Joonyong Jang4Moonki Jung5Jinuoung Kim6Seok Hoon Jeong7Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 06273, KoreaDepartment of Ophthalmology, Armed Forces Daegu Hospital, Daegu 712-906, KoreaDepartment of Internal Medicine, Armed Forces Daegu Hospital, Daegu 712-906, KoreaDepartment of Internal Medicine, Armed Forces Daegu Hospital, Daegu 712-906, KoreaDepartment of Internal Medicine, Armed Forces Daegu Hospital, Daegu 712-906, KoreaDepartment of Internal Medicine, Armed Forces Daegu Hospital, Daegu 712-906, KoreaDepartment of Internal Medicine, Armed Forces Daegu Hospital, Daegu 712-906, KoreaDepartment of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 06273, KoreaA rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020. The Korea Centers for Disease Control and Prevention (KCDC) classification system was used to triage patients. The clinical course was summarized, including the impact of drugs (angiotensin II receptor blockers [ARB], ibuprofen, and dipeptidyl peptidase-4 inhibitors [DPP4i]) and the therapeutic effect of lopinavir/ritonavir. After adjusting for confounding variables, prior history of drug use, including ARB, ibuprofen, and DPP4i was not a risk factor associated with disease progression. Patients treated with lopinavir/ritonavir had significantly shorter progression-free survival than those not receiving lopinavir/ritonavir. KCDC classification I clearly distinguished the improvement/stabilization group from the progression group of COVID-19 patients (AUC 0.817; 95% CI, 0.740–0.895).https://www.mdpi.com/2077-0383/9/6/1959coronavirus disease-19 (COVID-19)severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)angiotensin II receptor blockers (ARB)ibuprofenKorea centers for disease control and prevention (KCDC) classification |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Hyuk Choi Hyunmin Ahn Han Seok Ryu Byung-Jun Kim Joonyong Jang Moonki Jung Jinuoung Kim Seok Hoon Jeong |
spellingShingle |
Min Hyuk Choi Hyunmin Ahn Han Seok Ryu Byung-Jun Kim Joonyong Jang Moonki Jung Jinuoung Kim Seok Hoon Jeong Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea Journal of Clinical Medicine coronavirus disease-19 (COVID-19) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) angiotensin II receptor blockers (ARB) ibuprofen Korea centers for disease control and prevention (KCDC) classification |
author_facet |
Min Hyuk Choi Hyunmin Ahn Han Seok Ryu Byung-Jun Kim Joonyong Jang Moonki Jung Jinuoung Kim Seok Hoon Jeong |
author_sort |
Min Hyuk Choi |
title |
Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea |
title_short |
Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea |
title_full |
Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea |
title_fullStr |
Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea |
title_full_unstemmed |
Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea |
title_sort |
clinical characteristics and disease progression in early-stage covid-19 patients in south korea |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-06-01 |
description |
A rapid increase in the number of patients with coronavirus disease 19 (COVID-19) may overwhelm the available medical resources. We aimed to evaluate risk factors for disease severity in the early stages of COVID-19. The cohort comprised 293 patients with COVID-19 from 5 March 2020, to 18 March 2020. The Korea Centers for Disease Control and Prevention (KCDC) classification system was used to triage patients. The clinical course was summarized, including the impact of drugs (angiotensin II receptor blockers [ARB], ibuprofen, and dipeptidyl peptidase-4 inhibitors [DPP4i]) and the therapeutic effect of lopinavir/ritonavir. After adjusting for confounding variables, prior history of drug use, including ARB, ibuprofen, and DPP4i was not a risk factor associated with disease progression. Patients treated with lopinavir/ritonavir had significantly shorter progression-free survival than those not receiving lopinavir/ritonavir. KCDC classification I clearly distinguished the improvement/stabilization group from the progression group of COVID-19 patients (AUC 0.817; 95% CI, 0.740–0.895). |
topic |
coronavirus disease-19 (COVID-19) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) angiotensin II receptor blockers (ARB) ibuprofen Korea centers for disease control and prevention (KCDC) classification |
url |
https://www.mdpi.com/2077-0383/9/6/1959 |
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