Machine learning applications in cancer prognosis and prediction
Cancer has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become a necessity in cancer research, as it can facilitate the subsequent clinical management of patients. The importance of classifying cancer pat...
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doaj-35b9fc4c35f148889aab32c978d9a58b2020-11-24T23:28:50ZengElsevierComputational and Structural Biotechnology Journal2001-03702015-01-0113C81710.1016/j.csbj.2014.11.005Machine learning applications in cancer prognosis and predictionKonstantina Kourou0Themis P. Exarchos1Konstantinos P. Exarchos2Michalis V. Karamouzis3Dimitrios I. Fotiadis4Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, GreeceUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, GreeceUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, University of Athens, Athens, GreeceUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, GreeceCancer has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become a necessity in cancer research, as it can facilitate the subsequent clinical management of patients. The importance of classifying cancer patients into high or low risk groups has led many research teams, from the biomedical and the bioinformatics field, to study the application of machine learning (ML) methods. Therefore, these techniques have been utilized as an aim to model the progression and treatment of cancerous conditions. In addition, the ability of ML tools to detect key features from complex datasets reveals their importance. A variety of these techniques, including Artificial Neural Networks (ANNs), Bayesian Networks (BNs), Support Vector Machines (SVMs) and Decision Trees (DTs) have been widely applied in cancer research for the development of predictive models, resulting in effective and accurate decision making. Even though it is evident that the use of ML methods can improve our understanding of cancer progression, an appropriate level of validation is needed in order for these methods to be considered in the everyday clinical practice. In this work, we present a review of recent ML approaches employed in the modeling of cancer progression. The predictive models discussed here are based on various supervised ML techniques as well as on different input features and data samples. Given the growing trend on the application of ML methods in cancer research, we present here the most recent publications that employ these techniques as an aim to model cancer risk or patient outcomes.http://www.sciencedirect.com/science/article/pii/S2001037014000464Machine learningCancer susceptibilityPredictive modelsCancer recurrenceCancer survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Konstantina Kourou Themis P. Exarchos Konstantinos P. Exarchos Michalis V. Karamouzis Dimitrios I. Fotiadis |
spellingShingle |
Konstantina Kourou Themis P. Exarchos Konstantinos P. Exarchos Michalis V. Karamouzis Dimitrios I. Fotiadis Machine learning applications in cancer prognosis and prediction Computational and Structural Biotechnology Journal Machine learning Cancer susceptibility Predictive models Cancer recurrence Cancer survival |
author_facet |
Konstantina Kourou Themis P. Exarchos Konstantinos P. Exarchos Michalis V. Karamouzis Dimitrios I. Fotiadis |
author_sort |
Konstantina Kourou |
title |
Machine learning applications in cancer prognosis and prediction |
title_short |
Machine learning applications in cancer prognosis and prediction |
title_full |
Machine learning applications in cancer prognosis and prediction |
title_fullStr |
Machine learning applications in cancer prognosis and prediction |
title_full_unstemmed |
Machine learning applications in cancer prognosis and prediction |
title_sort |
machine learning applications in cancer prognosis and prediction |
publisher |
Elsevier |
series |
Computational and Structural Biotechnology Journal |
issn |
2001-0370 |
publishDate |
2015-01-01 |
description |
Cancer has been characterized as a heterogeneous disease consisting of many different subtypes. The early diagnosis and prognosis of a cancer type have become a necessity in cancer research, as it can facilitate the subsequent clinical management of patients. The importance of classifying cancer patients into high or low risk groups has led many research teams, from the biomedical and the bioinformatics field, to study the application of machine learning (ML) methods. Therefore, these techniques have been utilized as an aim to model the progression and treatment of cancerous conditions. In addition, the ability of ML tools to detect key features from complex datasets reveals their importance. A variety of these techniques, including Artificial Neural Networks (ANNs), Bayesian Networks (BNs), Support Vector Machines (SVMs) and Decision Trees (DTs) have been widely applied in cancer research for the development of predictive models, resulting in effective and accurate decision making. Even though it is evident that the use of ML methods can improve our understanding of cancer progression, an appropriate level of validation is needed in order for these methods to be considered in the everyday clinical practice. In this work, we present a review of recent ML approaches employed in the modeling of cancer progression. The predictive models discussed here are based on various supervised ML techniques as well as on different input features and data samples. Given the growing trend on the application of ML methods in cancer research, we present here the most recent publications that employ these techniques as an aim to model cancer risk or patient outcomes. |
topic |
Machine learning Cancer susceptibility Predictive models Cancer recurrence Cancer survival |
url |
http://www.sciencedirect.com/science/article/pii/S2001037014000464 |
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