Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Here the authors show that this may be explained by desensitization of GIPR activity by chronic GIP...
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Bibliographic Details
| Main Authors: |
Elizabeth A. Killion,
Michelle Chen,
James R. Falsey,
Glenn Sivits,
Todd Hager,
Larissa Atangan,
Joan Helmering,
Jae Lee,
Hongyan Li,
Bin Wu,
Yuan Cheng,
Murielle M. Véniant,
David J. Lloyd |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18751-8
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