Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients

The PI3K pathway is altered across various cancer types. Here the authors use amplicon exon sequencing to analyze the landscape of somatic mutations affecting the PI3K pathway specifically in breast cancer patients in China.

Bibliographic Details
Main Authors:	Li Chen, Liu Yang, Ling Yao, Xia-Ying Kuang, Wen-Jia Zuo, Shan Li, Feng Qiao, Yi-Rong Liu, Zhi-Gang Cao, Shu-Ling Zhou, Xiao-Yan Zhou, Wen-Tao Yang, Jin-Xiu Shi, Wei Huang, Xin Hu, Zhi-Ming Shao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03867-9

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spelling	doaj-35be9cbfd9d943158a629a540eb68b222021-05-11T09:39:26ZengNature Publishing GroupNature Communications2041-17232018-04-019111710.1038/s41467-018-03867-9Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patientsLi Chen0Liu Yang1Ling Yao2Xia-Ying Kuang3Wen-Jia Zuo4Shan Li5Feng Qiao6Yi-Rong Liu7Zhi-Gang Cao8Shu-Ling Zhou9Xiao-Yan Zhou10Wen-Tao Yang11Jin-Xiu Shi12Wei Huang13Xin Hu14Zhi-Ming Shao15Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterDepartment of Breast Surgery, The First Affiliated Hospital, Sun Yat-Sen UniversityKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI)Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI)Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer CenterThe PI3K pathway is altered across various cancer types. Here the authors use amplicon exon sequencing to analyze the landscape of somatic mutations affecting the PI3K pathway specifically in breast cancer patients in China.https://doi.org/10.1038/s41467-018-03867-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Li Chen Liu Yang Ling Yao Xia-Ying Kuang Wen-Jia Zuo Shan Li Feng Qiao Yi-Rong Liu Zhi-Gang Cao Shu-Ling Zhou Xiao-Yan Zhou Wen-Tao Yang Jin-Xiu Shi Wei Huang Xin Hu Zhi-Ming Shao
spellingShingle	Li Chen Liu Yang Ling Yao Xia-Ying Kuang Wen-Jia Zuo Shan Li Feng Qiao Yi-Rong Liu Zhi-Gang Cao Shu-Ling Zhou Xiao-Yan Zhou Wen-Tao Yang Jin-Xiu Shi Wei Huang Xin Hu Zhi-Ming Shao Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients Nature Communications
author_facet	Li Chen Liu Yang Ling Yao Xia-Ying Kuang Wen-Jia Zuo Shan Li Feng Qiao Yi-Rong Liu Zhi-Gang Cao Shu-Ling Zhou Xiao-Yan Zhou Wen-Tao Yang Jin-Xiu Shi Wei Huang Xin Hu Zhi-Ming Shao
author_sort	Li Chen
title	Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
title_short	Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
title_full	Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
title_fullStr	Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
title_full_unstemmed	Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
title_sort	characterization of pik3ca and pik3r1 somatic mutations in chinese breast cancer patients
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-04-01
description	The PI3K pathway is altered across various cancer types. Here the authors use amplicon exon sequencing to analyze the landscape of somatic mutations affecting the PI3K pathway specifically in breast cancer patients in China.
url	https://doi.org/10.1038/s41467-018-03867-9
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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients

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