Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer
Next generation sequencing has accelerated the discovery of a variety of new fusion gene types in clinical breast cancer samples by analyzing cancer genomes and transcriptomes. Although previous studies have focused on a few clinically validated oncogenic fusion genes as diagnostic and therapeutic t...
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doaj-35bfe8a61302434c86b282754bdcfea52020-11-24T20:47:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-02-0119250210.3390/ijms19020502ijms19020502Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast CancerRyong Nam Kim0Hyeong-Gon Moon1Wonshik Han2Dong-Young Noh3Center for Medical Innovation, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Surgery, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Surgery, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Surgery, Seoul National University College of Medicine, Seoul 03080, KoreaNext generation sequencing has accelerated the discovery of a variety of new fusion gene types in clinical breast cancer samples by analyzing cancer genomes and transcriptomes. Although previous studies have focused on a few clinically validated oncogenic fusion genes as diagnostic and therapeutic targets in breast cancer, a perspective consideration has not been given thus far for a plethora of breast cancer fusion genes, which are being newly identified at an overwhelmingly increasing pace. In this perspective review, we discuss diverse fusion gene types recently identified in a variety of breast cancer subtypes, including breast clinical cancer samples in TCGA (The Cancer Genome Atlas) database. This perspective review will confer fresh and promising guidance onto breast cancer surgeons, clinical oncologists, and tumor biologists in determining research directions for seeking and developing novel fusion gene biomarkers for breast cancer diagnostics and therapeutic treatment in upcoming years.http://www.mdpi.com/1422-0067/19/2/502fusion gene transcriptbreast cancerbiomarker |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryong Nam Kim Hyeong-Gon Moon Wonshik Han Dong-Young Noh |
spellingShingle |
Ryong Nam Kim Hyeong-Gon Moon Wonshik Han Dong-Young Noh Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer International Journal of Molecular Sciences fusion gene transcript breast cancer biomarker |
author_facet |
Ryong Nam Kim Hyeong-Gon Moon Wonshik Han Dong-Young Noh |
author_sort |
Ryong Nam Kim |
title |
Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer |
title_short |
Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer |
title_full |
Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer |
title_fullStr |
Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer |
title_full_unstemmed |
Perspective Insight into Future Potential Fusion Gene Transcript Biomarker Candidates in Breast Cancer |
title_sort |
perspective insight into future potential fusion gene transcript biomarker candidates in breast cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-02-01 |
description |
Next generation sequencing has accelerated the discovery of a variety of new fusion gene types in clinical breast cancer samples by analyzing cancer genomes and transcriptomes. Although previous studies have focused on a few clinically validated oncogenic fusion genes as diagnostic and therapeutic targets in breast cancer, a perspective consideration has not been given thus far for a plethora of breast cancer fusion genes, which are being newly identified at an overwhelmingly increasing pace. In this perspective review, we discuss diverse fusion gene types recently identified in a variety of breast cancer subtypes, including breast clinical cancer samples in TCGA (The Cancer Genome Atlas) database. This perspective review will confer fresh and promising guidance onto breast cancer surgeons, clinical oncologists, and tumor biologists in determining research directions for seeking and developing novel fusion gene biomarkers for breast cancer diagnostics and therapeutic treatment in upcoming years. |
topic |
fusion gene transcript breast cancer biomarker |
url |
http://www.mdpi.com/1422-0067/19/2/502 |
work_keys_str_mv |
AT ryongnamkim perspectiveinsightintofuturepotentialfusiongenetranscriptbiomarkercandidatesinbreastcancer AT hyeonggonmoon perspectiveinsightintofuturepotentialfusiongenetranscriptbiomarkercandidatesinbreastcancer AT wonshikhan perspectiveinsightintofuturepotentialfusiongenetranscriptbiomarkercandidatesinbreastcancer AT dongyoungnoh perspectiveinsightintofuturepotentialfusiongenetranscriptbiomarkercandidatesinbreastcancer |
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1716810700871958528 |