Association between Platelet-Specific Collagen Receptor Glycoprotein 6 Gene Variants, Selected Biomarkers, and Recurrent Pregnancy Loss in Korean Women

• Main Authors: Hui Jeong An, Eun Hee Ahn, Jung Oh Kim, Chang Soo Ryu, Han Sung Park, Sung Hwan Cho, Ji Hyang Kim, Woo Sik Lee, Jung Ryeol Lee, Young Ran Kim, Nam Keun Kim
• Format: Article
• Language: English
• Published: MDPI AG 2020-07-01
• Series: Genes
• Subjects: glycoprotein 6 (<i>GP6</i>); recurrent pregnancy loss; polymorphism; platelet; miRNA
• Online Access: https://www.mdpi.com/2073-4425/11/8/862

This paper investigates whether glycoprotein 6 (<i>GP6</i>) gene polymorphisms are a risk factor for recurrent pregnancy loss (RPL) in Korean women. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and real-time polymerase chain reaction amplification. We identified five polymorphisms in the <i>GP6</i> gene: rs1654410 T>C, rs1671153 T>G, rs1654419 G>A, rs12610286 A>G, and rs1654431 G>A. <i>GP6</i> rs1654410 CC was associated with decreased RPL risk (adjusted odds ratio = 0.292, 95% confidence interval = 0.105–0.815, <i>p</i> = 0.019), and recessive genotypes were also significantly associated with decreased RPL risk (adjusted odds ratio = 0.348, 95% confidence interval = 0.128−0.944, <i>p</i> = 0.038). <i>GP6</i> rs1654419 GA was associated with decreased RPL risk (adjusted odds ratio = 0.607, 95% confidence interval = 0.375-0.982, <i>p</i> = 0.042), and dominant genotypes were significantly associated with decreased RPL risk (adjusted odds ratio = 0.563, 95% confidence interval = 0.358−0.885, <i>p</i> = 0.013). Altogether, the genotype frequencies of <i>GP6</i> rs1654410 T>C and <i>GP6</i> rs1654419 G>A were significantly different between RPL patients and control participants. Therefore, although <i>GP6</i> polymorphisms may be useful as biomarkers of RPL, additional studies with heterogeneous cohorts are required to better understand the influence of GP6 and assess its performance as a biomarker.