The T-type Ca2+ Channel Inhibitor Mibefradil Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

The T-type Ca2+ Channel Inhibitor Mibefradil Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

We examined the effects of mibefradil, a T-type Ca2+ channel inhibitor, on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells using the whole-cell patch clamp technique. Mibefradil reduced the Kv current amplitude in a dose-dependent manner, with an apparent Kd value...

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Bibliographic Details
Main Authors: Da Hye Hong, Dongki Yang, Il-Whan Choi, Youn Kyoung Son, Won-Kyo Jung, Dae-Joong Kim, Jin Han, Sung Hun Na, Won Sun Park
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319304347

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