Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Development Drugs Against Cancer

Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Development Drugs Against Cancer

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the malignant phenotype. The hexosamine biosynthetic pathway (HBP) is a branch of glucose metabolism that produces UDP-GlcNAc, and its derivatives, UDP-GalNAc and CMP-Neu5Ac, donor substrates used in the production of...

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Bibliographic Details
Main Authors: Andreia eVasconcelos-dos-Santos, Isadora A. Oliveira, Miguel Clodomiro Lucena, Natalia Rodrigues Mantuano, Stephen A. Whelan, Wagner Barbosa Dias, Adriane Regina Todeschini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Oncology
Subjects:
Glycoconjugates
Glycoproteins
Glycosylation
Glycosyltransferases
Cancer
chemotherapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00138/full

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