The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage
Biomechanical factors play an extremely important role in regulating the function of articular chondrocytes. Understanding the mechanical factors that drive chondrocyte biological responses is at the heart of our interpretation of cascade events leading to changes in articular cartilage osteoarthrit...
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2020-08-01
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Series: | Journal of Orthopaedic Surgery |
Online Access: | https://doi.org/10.1177/2309499020950262 |
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doaj-35e75beef02840678f9dbc83b463a6d22020-11-25T03:39:30ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902020-08-012810.1177/2309499020950262The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilageBo-Yang Xu0Yu Jin1Xiao-Hui Ma2Chi-Yu Wang3Yi Guo4Dan Zhou5 School of Acupuncture-Moxibustion and Tuina, , Tianjin, People’s Republic of China School of Chinese Medicine, , Tianjin, People’s Republic of China School of Culture and Health Communication, , Tianjin, People’s Republic of China Department of Electrical Engineering and Computer Sciences, , CA, USA National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, People’s Republic of ChinaBiomechanical factors play an extremely important role in regulating the function of articular chondrocytes. Understanding the mechanical factors that drive chondrocyte biological responses is at the heart of our interpretation of cascade events leading to changes in articular cartilage osteoarthritis. The mechanism by which mechanical load is transduced into intracellular signals that can regulate chondrocyte gene expression remains largely unknown. The mechanically sensitive ion channel (MSC) may be one of its specific mechanisms. This review focuses on four ion channels involved in the mechanotransduction of chondrocytes, exploring their properties and the main factors that activate the associated pathways. The upstream and downstream potential relationships between the protein pathways were also explored. The specific biophysical mechanism of the chondrocyte mechanical microenvironment is becoming the focus of research. Elucidating the mechanotransduction mechanism of MSC is essential for the research of biophysical pathogenesis and targeted drugs in cartilage injury-related diseases.https://doi.org/10.1177/2309499020950262 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo-Yang Xu Yu Jin Xiao-Hui Ma Chi-Yu Wang Yi Guo Dan Zhou |
spellingShingle |
Bo-Yang Xu Yu Jin Xiao-Hui Ma Chi-Yu Wang Yi Guo Dan Zhou The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage Journal of Orthopaedic Surgery |
author_facet |
Bo-Yang Xu Yu Jin Xiao-Hui Ma Chi-Yu Wang Yi Guo Dan Zhou |
author_sort |
Bo-Yang Xu |
title |
The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage |
title_short |
The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage |
title_full |
The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage |
title_fullStr |
The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage |
title_full_unstemmed |
The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage |
title_sort |
potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage |
publisher |
SAGE Publishing |
series |
Journal of Orthopaedic Surgery |
issn |
2309-4990 |
publishDate |
2020-08-01 |
description |
Biomechanical factors play an extremely important role in regulating the function of articular chondrocytes. Understanding the mechanical factors that drive chondrocyte biological responses is at the heart of our interpretation of cascade events leading to changes in articular cartilage osteoarthritis. The mechanism by which mechanical load is transduced into intracellular signals that can regulate chondrocyte gene expression remains largely unknown. The mechanically sensitive ion channel (MSC) may be one of its specific mechanisms. This review focuses on four ion channels involved in the mechanotransduction of chondrocytes, exploring their properties and the main factors that activate the associated pathways. The upstream and downstream potential relationships between the protein pathways were also explored. The specific biophysical mechanism of the chondrocyte mechanical microenvironment is becoming the focus of research. Elucidating the mechanotransduction mechanism of MSC is essential for the research of biophysical pathogenesis and targeted drugs in cartilage injury-related diseases. |
url |
https://doi.org/10.1177/2309499020950262 |
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