Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody
bjective: The most common coexisting organ-specific autoimmune disease in patients with type 1 diabetes mellitus (T1DM) is autoimmune thyroid dise ase (AITD). However, there have been few clinical reports based on a large populatio n about the prevalence of zinc transporter 8 autoantibody (ZnT8A) an...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Bioscientifica
2021-05-01
|
Series: | Endocrine Connections |
Subjects: | |
Online Access: | https://ec.bioscientifica.com/view/journals/ec/10/5/EC-20-0650.xml |
id |
doaj-35ec45121d7f441eada90d7db74e0fc7 |
---|---|
record_format |
Article |
spelling |
doaj-35ec45121d7f441eada90d7db74e0fc72021-05-21T05:15:54ZengBioscientificaEndocrine Connections2049-36142049-36142021-05-01105534542https://doi.org/10.1530/EC-20-0650Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibodyYun Cai0Jieni Yan1Yong Gu2Heng Chen3Yang Chen4Xinyu Xu5Mei Zhang6Liping Yu7Xuqin Zheng8Tao Yang9Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USADepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Chinabjective: The most common coexisting organ-specific autoimmune disease in patients with type 1 diabetes mellitus (T1DM) is autoimmune thyroid dise ase (AITD). However, there have been few clinical reports based on a large populatio n about the prevalence of zinc transporter 8 autoantibody (ZnT8A) and other islet auto antibodies in AITD patients. We aimed to explore the presence of islet autoantibod ies, ZnT8A, glutamic acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen 2 autoantibodies (IA-2A) compared with thyroid autoantibodies, thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TGAb) and thyrotropin receptor autoantibodies (TRAb) in patients with Graves’ disease (GD), Hashimoto’s thyroiditis (HT) and T1DM patients with AITD. Methods: Totally, 389 patients with GD, 334 patients with HT, 108 T1DM patients with AITD and 115 healthy controls (HC) were recruited in the study. Islet autoantibodies (ZnT8A, GADA and IA-2A) were detected by radioligand binding as say. Thyroid autoantibodies, TPOAb and TGAb were detected by chemiluminescen ce assay, and TRAb was detected by RIA. Results: The prevalence of ZnT8A, GADA and IA-2A was higher in GD and H T patients than that of HC (ZnT8A: GD 8.48%, HT 10.8% vs HC 1.74%; GADA: GD 7.4 6%, HT 7.74% vs HC 0.870%; IA-2A: GD 4.88%, HT 3.59% vs HC 0%; All P < 0.05) but lower than that of T1DM subjects with AITD (ZnT8A: 42.6%; IA-2A: 44.4%; GADA: 74.1%; al l P < 0.0001). Conclusions: An increased prevalence of ZnT8A as well as GADA and IA-2A was found in both GD and HT patients, indicating that there is a potentia l link between thyroid autoimmunity and islet autoimmunity. https://ec.bioscientifica.com/view/journals/ec/10/5/EC-20-0650.xmlautoimmune thyroid diseasetype 1 diabetes mellituszinc transporter 8 autoantibodythyroid peroxidase autoantibodies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun Cai Jieni Yan Yong Gu Heng Chen Yang Chen Xinyu Xu Mei Zhang Liping Yu Xuqin Zheng Tao Yang |
spellingShingle |
Yun Cai Jieni Yan Yong Gu Heng Chen Yang Chen Xinyu Xu Mei Zhang Liping Yu Xuqin Zheng Tao Yang Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody Endocrine Connections autoimmune thyroid disease type 1 diabetes mellitus zinc transporter 8 autoantibody thyroid peroxidase autoantibodies |
author_facet |
Yun Cai Jieni Yan Yong Gu Heng Chen Yang Chen Xinyu Xu Mei Zhang Liping Yu Xuqin Zheng Tao Yang |
author_sort |
Yun Cai |
title |
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody |
title_short |
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody |
title_full |
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody |
title_fullStr |
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody |
title_full_unstemmed |
Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody |
title_sort |
autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2021-05-01 |
description |
bjective: The most common coexisting organ-specific autoimmune disease in patients with type 1 diabetes mellitus (T1DM) is autoimmune thyroid dise ase (AITD). However, there have been few clinical reports based on a large populatio n about the prevalence of zinc transporter 8 autoantibody (ZnT8A) and other islet auto antibodies in AITD patients. We aimed to explore the presence of islet autoantibod ies, ZnT8A, glutamic acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen 2 autoantibodies (IA-2A) compared with thyroid autoantibodies, thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TGAb) and thyrotropin receptor autoantibodies (TRAb) in patients with Graves’ disease (GD), Hashimoto’s thyroiditis (HT) and T1DM patients with AITD.
Methods: Totally, 389 patients with GD, 334 patients with HT, 108 T1DM patients with AITD and 115 healthy controls (HC) were recruited in the study. Islet autoantibodies (ZnT8A, GADA and IA-2A) were detected by radioligand binding as say. Thyroid autoantibodies, TPOAb and TGAb were detected by chemiluminescen ce assay, and TRAb was detected by RIA.
Results: The prevalence of ZnT8A, GADA and IA-2A was higher in GD and H T patients than that of HC (ZnT8A: GD 8.48%, HT 10.8% vs HC 1.74%; GADA: GD 7.4 6%, HT 7.74% vs HC 0.870%; IA-2A: GD 4.88%, HT 3.59% vs HC 0%; All P < 0.05) but lower than that of T1DM subjects with AITD (ZnT8A: 42.6%; IA-2A: 44.4%; GADA: 74.1%; al l P < 0.0001).
Conclusions: An increased prevalence of ZnT8A as well as GADA and IA-2A was found in both GD and HT patients, indicating that there is a potentia l link between thyroid autoimmunity and islet autoimmunity.
|
topic |
autoimmune thyroid disease type 1 diabetes mellitus zinc transporter 8 autoantibody thyroid peroxidase autoantibodies |
url |
https://ec.bioscientifica.com/view/journals/ec/10/5/EC-20-0650.xml |
work_keys_str_mv |
AT yuncai autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT jieniyan autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT yonggu autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT hengchen autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT yangchen autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT xinyuxu autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT meizhang autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT lipingyu autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT xuqinzheng autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody AT taoyang autoimmunethyroiddiseasecorrelatestoisletautoimmunityonzinctransporter8autoantibody |
_version_ |
1721432501920989184 |