Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models
Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achil...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2011-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1093/ecam/nep039 |
id |
doaj-35ef5c643feb4ea19a60f12cf83e838e |
---|---|
record_format |
Article |
spelling |
doaj-35ef5c643feb4ea19a60f12cf83e838e2020-11-24T21:32:44ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882011-01-01201110.1093/ecam/nep039474026Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision ModelsEsra Küpeli Akkol0Ufuk Koca1Ipek Pesin2Demet Yilmazer3Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, TurkeyDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, TurkeyDepartment of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, TurkeyDepartment of Pathology, Dışkapı Yıldırım Beyazit Education and Research Hospital, Ankara, TurkeyAchillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were employed on mice and rats. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol. The n-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol (100%). On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups. The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well. The experimental data demonstrated that A. biebersteinii displayed remarkable wound healing activity.http://dx.doi.org/10.1093/ecam/nep039 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Esra Küpeli Akkol Ufuk Koca Ipek Pesin Demet Yilmazer |
spellingShingle |
Esra Küpeli Akkol Ufuk Koca Ipek Pesin Demet Yilmazer Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models Evidence-Based Complementary and Alternative Medicine |
author_facet |
Esra Küpeli Akkol Ufuk Koca Ipek Pesin Demet Yilmazer |
author_sort |
Esra Küpeli Akkol |
title |
Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models |
title_short |
Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models |
title_full |
Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models |
title_fullStr |
Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models |
title_full_unstemmed |
Evaluation of the Wound Healing Potential of Achillea biebersteinii Afan. (Asteraceae) by In Vivo Excision and Incision Models |
title_sort |
evaluation of the wound healing potential of achillea biebersteinii afan. (asteraceae) by in vivo excision and incision models |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2011-01-01 |
description |
Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were employed on mice and rats. The wound healing effect was comparatively evaluated with the standard skin ointment Madecassol. The n-hexane extract treated groups of animals showed 84.2% contraction, which was close to contraction value of the reference drug Madecassol (100%). On the other hand the same extract on incision wound model demonstrated a significant increase (40.1%) in wound tensile strength as compared to other groups. The results of histoptological examination supported the outcome of linear incision and circular excision wound models as well. The experimental data demonstrated that A. biebersteinii displayed remarkable wound healing activity. |
url |
http://dx.doi.org/10.1093/ecam/nep039 |
work_keys_str_mv |
AT esrakupeliakkol evaluationofthewoundhealingpotentialofachilleabiebersteiniiafanasteraceaebyinvivoexcisionandincisionmodels AT ufukkoca evaluationofthewoundhealingpotentialofachilleabiebersteiniiafanasteraceaebyinvivoexcisionandincisionmodels AT ipekpesin evaluationofthewoundhealingpotentialofachilleabiebersteiniiafanasteraceaebyinvivoexcisionandincisionmodels AT demetyilmazer evaluationofthewoundhealingpotentialofachilleabiebersteiniiafanasteraceaebyinvivoexcisionandincisionmodels |
_version_ |
1725956274732924928 |