Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ.

Latent TGFβ binding proteins (LTBPs) regulate the extracellular availability of latent TGFβ. LTBP4 was identified as a genetic modifier of muscular dystrophy in mice and humans. An in-frame insertion polymorphism in the murine Ltbp4 gene associates with partial protection against muscular dystrophy....

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Bibliographic Details
Main Authors: Kay-Marie Lamar, Sasha Bogdanovich, Brandon B Gardner, Quan Q Gao, Tamari Miller, Judy U Earley, Michele Hadhazy, Andy H Vo, Lisa Wren, Jeffery D Molkentin, Elizabeth M McNally
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1006019

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