Engineering protein assemblies with allosteric control via monomer fold-switching
The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13686-1 |
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doaj-35fa5f2626334f038b8530ed1e35e4fe2021-05-11T12:33:45ZengNature Publishing GroupNature Communications2041-17232019-12-0110111310.1038/s41467-019-13686-1Engineering protein assemblies with allosteric control via monomer fold-switchingLuis A. Campos0Rajendra Sharma1Sara Alvira2Federico M. Ruiz3Beatriz Ibarra-Molero4Mourad Sadqi5Carlos Alfonso6Germán Rivas7Jose M. Sanchez-Ruiz8Antonio Romero Garrido9José M. Valpuesta10Victor Muñoz11Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro de Investigaciones Biológicas (CIB-CSIC)Departamento de Química Física, Facultad de Ciencias, Universidad de GranadaDepartment of Bioengineering, University of CaliforniaCentro de Investigaciones Biológicas (CIB-CSIC)Centro de Investigaciones Biológicas (CIB-CSIC)Departamento de Química Física, Facultad de Ciencias, Universidad de GranadaCentro de Investigaciones Biológicas (CIB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.https://doi.org/10.1038/s41467-019-13686-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz |
| spellingShingle |
Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz Engineering protein assemblies with allosteric control via monomer fold-switching Nature Communications |
| author_facet |
Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz |
| author_sort |
Luis A. Campos |
| title |
Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_short |
Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_full |
Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_fullStr |
Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_full_unstemmed |
Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_sort |
engineering protein assemblies with allosteric control via monomer fold-switching |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-12-01 |
| description |
The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly. |
| url |
https://doi.org/10.1038/s41467-019-13686-1 |
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