The role of infection in morphea disease
Morphea is a skin disorder that leads to the sclerosis of the dermis and subcutaneous tissue. In epidemiologic studies, the incidence rate of approximately 0.4 to 2.7 per 100,000 people has been reported that is equal in adults and children. Based on clinical findings of disease and presentations, m...
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Mashhad University of Medical Sciences
2015-09-01
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doaj-36049867248345d292aa4752f63c57a72020-11-24T22:33:26ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922015-09-01241871894762The role of infection in morphea diseaseFatemeh Farhangdoost0Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Morphea is a skin disorder that leads to the sclerosis of the dermis and subcutaneous tissue. In epidemiologic studies, the incidence rate of approximately 0.4 to 2.7 per 100,000 people has been reported that is equal in adults and children. Based on clinical findings of disease and presentations, morphea disease has been divided into four major types including plaque-type, linear, generalized and a miscellaneous group with morphologically distinct phenotypes. Overall, plaque-type is the most common type of morphea. This disease is characterized by three main histopathologic features that include deposition of collagen in the dermis sometimes with extension to subcutis, vascular changes and an inflammatory cell infiltration, particularly in early lesions. Morphea is a multifactorial process that its main underlying cause is not completely known but the most common causes related to the genesis of morphea including trauma, radiation, medications, infection, autoimmunity and microchimerism. In this paper, we review the literature about the role of infection in the genesis of morphea.http://rcm.mums.ac.ir/pdf_4762_7703e1f21da06c88067d69726a64c839.htmlBorreliaCytomegalovirusInfectionMorphea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatemeh Farhangdoost |
spellingShingle |
Fatemeh Farhangdoost The role of infection in morphea disease Reviews in Clinical Medicine Borrelia Cytomegalovirus Infection Morphea |
author_facet |
Fatemeh Farhangdoost |
author_sort |
Fatemeh Farhangdoost |
title |
The role of infection in morphea disease |
title_short |
The role of infection in morphea disease |
title_full |
The role of infection in morphea disease |
title_fullStr |
The role of infection in morphea disease |
title_full_unstemmed |
The role of infection in morphea disease |
title_sort |
role of infection in morphea disease |
publisher |
Mashhad University of Medical Sciences |
series |
Reviews in Clinical Medicine |
issn |
2345-6256 2345-6892 |
publishDate |
2015-09-01 |
description |
Morphea is a skin disorder that leads to the sclerosis of the dermis and subcutaneous tissue. In epidemiologic studies, the incidence rate of approximately 0.4 to 2.7 per 100,000 people has been reported that is equal in adults and children. Based on clinical findings of disease and presentations, morphea disease has been divided into four major types including plaque-type, linear, generalized and a miscellaneous group with morphologically distinct phenotypes. Overall, plaque-type is the most common type of morphea. This disease is characterized by three main histopathologic features that include deposition of collagen in the dermis sometimes with extension to subcutis, vascular changes and an inflammatory cell infiltration, particularly in early lesions. Morphea is a multifactorial process that its main underlying cause is not completely known but the most common causes related to the genesis of morphea including trauma, radiation, medications, infection, autoimmunity and microchimerism. In this paper, we review the literature about the role of infection in the genesis of morphea. |
topic |
Borrelia Cytomegalovirus Infection Morphea |
url |
http://rcm.mums.ac.ir/pdf_4762_7703e1f21da06c88067d69726a64c839.html |
work_keys_str_mv |
AT fatemehfarhangdoost theroleofinfectioninmorpheadisease AT fatemehfarhangdoost roleofinfectioninmorpheadisease |
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