White Matter Integrity Involvement in the Preclinical Stage of Familial Creutzfeldt–Jakob Disease: A Diffusion Tensor Imaging Study

White Matter Integrity Involvement in the Preclinical Stage of Familial Creutzfeldt–Jakob Disease: A Diffusion Tensor Imaging Study

ObjectiveThe objective of the study was to explore patterns of white matter (WM) alteration in preclinical stage familial Creutzfeldt–Jakob disease (fCJD) using diffusion tensor imaging (DTI).MethodsSeven asymptomatic carriers of the PRNP G114V mutation and six non-carriers were recruited from the s...

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Main Authors: Donglai Jing, Yaojing Chen, Kexin Xie, Yue Cui, Chunlei Cui, Li Liu, Hui Lu, Jing Ye, Ran Gao, Lin Wang, Zhigang Liang, Zhanjun Zhang, Liyong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Creutzfeldt–Jakob disease
preclinical stage
diffusion tensor imaging
tract-based spatial statistics
white matter
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.655667/full

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