Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital
Objective: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases. Materials and Methods: A prospective observational study was carried out in a superspeciality hospital setting...
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Wolters Kluwer Medknow Publications
2015-04-01
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Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.154194 |
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doaj-360f68c8f3a549afaf3c0e5714c7c2be2021-08-09T23:41:07ZengWolters Kluwer Medknow PublicationsAvicenna Journal of Medicine2231-07702249-44642015-04-010502293510.4103/2231-0770.154194Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospitalDivya Sivva0Uday Venkat Mateti1Venu Madhav Neerati2Nimbagiri Swamy Thiruthopu3Srinivas Martha4Department of Pharmacy Practice, St. Peter′s Institute of Pharmaceutical Sciences, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, IndiaManipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, IndiaPharmaceutical Analysis, St. Peter′s Institute of Pharmaceutical Sciences, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, IndiaDepartment of Pharmacy Practice, St. Peter′s Institute of Pharmaceutical Sciences, Kakatiya University, Hanamkonda, Warangal, Andhra Pradesh, IndiaDepartment of Pharmacology, Balaji Institute of Pharmacy, Laknepally, Narsampet, Warangal, Telangana, IndiaObjective: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases. Materials and Methods: A prospective observational study was carried out in a superspeciality hospital setting in South India for period of 9 months. Hypertensive patients who admitted into the hospital with the age more than 18 years, received more than 3 drugs per prescription and length of hospital stay for more than 24 hours were included in the study. An appropriate data was collected and assessed for DDIs with the help of Micromedex and Medscape databases. Results: A total of 227 patients were enrolled during the study period. Among the 227 patients, 48 of them developed 53 clinically significant DDIs. Out of 48 patients, most of them were in the age-group of 50-60 years [18 (37.49%)]. The percentage of DDIs were higher in males [30 (62.5%)] compared to females [18 (37.5%)]. The most common drugs responsible for DDIs in the present study were Insulin [18 (33.96%)] followed by Metoprolol [10 (18.86%)], Torsemide [8 (15.09%)], and Hydrochlorothiazide [8 (15.09%)]. The most commonly interacting pairs were Ciprofloxacin-Insulin [6 (11.32%)], followed by Metoprolol-Insulin [4 (7.54%)] and Atenolol-Insulin [4 (7.54%)]. The most common consequences of interacting pairs were reduced serum potassium levels and hyperglycemia. Conclusion: The overall incidence rate of DDIs was found to be 21.14% and the increasing number of co-morbidities ( P ≤ 0.003) and polypharmacy ( P ≤ 0.002) were the risk factor for the development of significant number of DDIs.http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.154194drug-drug interactionshypertensionincidencemicromedexmedscape |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Divya Sivva Uday Venkat Mateti Venu Madhav Neerati Nimbagiri Swamy Thiruthopu Srinivas Martha |
spellingShingle |
Divya Sivva Uday Venkat Mateti Venu Madhav Neerati Nimbagiri Swamy Thiruthopu Srinivas Martha Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital Avicenna Journal of Medicine drug-drug interactions hypertension incidence micromedex medscape |
author_facet |
Divya Sivva Uday Venkat Mateti Venu Madhav Neerati Nimbagiri Swamy Thiruthopu Srinivas Martha |
author_sort |
Divya Sivva |
title |
Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital |
title_short |
Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital |
title_full |
Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital |
title_fullStr |
Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital |
title_full_unstemmed |
Assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital |
title_sort |
assessment of drug-drug interactions in hypertensive patients at a superspeciality hospital |
publisher |
Wolters Kluwer Medknow Publications |
series |
Avicenna Journal of Medicine |
issn |
2231-0770 2249-4464 |
publishDate |
2015-04-01 |
description |
Objective: The objective of the study was to assess the incidence and pattern of drug-drug interactions (DDIs) in hypertensive patients by using Micromedex and Medscape databases.
Materials and Methods: A prospective observational study was carried out in a superspeciality hospital setting in South India for period of 9 months. Hypertensive patients who admitted into the hospital with the age more than 18 years, received more than 3 drugs per prescription and length of hospital stay for more than 24 hours were included in the study. An appropriate data was collected and assessed for DDIs with the help of Micromedex and Medscape databases.
Results: A total of 227 patients were enrolled during the study period. Among the 227 patients, 48 of them developed 53 clinically significant DDIs. Out of 48 patients, most of them were in the age-group of 50-60 years [18 (37.49%)]. The percentage of DDIs were higher in males [30 (62.5%)] compared to females [18 (37.5%)]. The most common drugs responsible for DDIs in the present study were Insulin [18 (33.96%)] followed by Metoprolol [10 (18.86%)], Torsemide [8 (15.09%)], and Hydrochlorothiazide [8 (15.09%)]. The most commonly interacting pairs were Ciprofloxacin-Insulin [6 (11.32%)], followed by Metoprolol-Insulin [4 (7.54%)] and Atenolol-Insulin [4 (7.54%)]. The most common consequences of interacting pairs were reduced serum potassium levels and hyperglycemia.
Conclusion: The overall incidence rate of DDIs was found to be 21.14% and the increasing number of co-morbidities ( P ≤ 0.003) and polypharmacy ( P ≤ 0.002) were the risk factor for the development of significant number of DDIs. |
topic |
drug-drug interactions hypertension incidence micromedex medscape |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.154194 |
work_keys_str_mv |
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