Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity

<p>Abstract</p> <p>Background</p> <p>Some clinical symptoms or cognitive functions have been related to the overall state of monoamine activity in patients with schizophrenia, (e.g. inverse correlation of the dopamine metabolite HVA with delusions or visual-masking perf...

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Main Authors: Henning Uwe, Röpcke Bernd, Oades Robert D, Klimke Ansgard
Format: Article
Language:English
Published: BMC 2005-08-01
Series:Behavioral and Brain Functions
Subjects:
Online Access:http://www.behavioralandbrainfunctions.com/content/1/1/14
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spelling doaj-360fff48dfb440a6969c9dd1d0e3fc162020-11-25T00:44:44ZengBMCBehavioral and Brain Functions1744-90812005-08-01111410.1186/1744-9081-1-14Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activityHenning UweRöpcke BerndOades Robert DKlimke Ansgard<p>Abstract</p> <p>Background</p> <p>Some clinical symptoms or cognitive functions have been related to the overall state of monoamine activity in patients with schizophrenia, (e.g. inverse correlation of the dopamine metabolite HVA with delusions or visual-masking performance). However, profiles (as presented here) of the relations of the activity of dopamine, noradrenaline and serotonin to neuropsychologic (dys)functions in major patient sub-groups with their very different symptomatic and cognitive characteristics have not been reported.</p> <p>Methods</p> <p>Serum measures of dopamine, noradrenaline and serotonin turnover were examined by regression analyses for the prediction of performance on 10 neuropsychological measures reflecting left- and right-hemispheric and frontal-, parietal- and temporal-lobe function in 108 patients with schizophrenia and 63 matched controls. The neuropsychological battery included tests of verbal fluency, Stroop interference, trail-making, block-design, Mooney faces recognition, picture-completion, immediate and delayed visual and verbal recall. Paranoid and nonparanoid subgroups were based on ratings from the Positive and Negative Syndrome Scale (PANSS). Groups with high and low ratings of ideas-of-reference and thought-disorder were formed from a median split on the Scale for Assessment of Positive Symptoms (SAPS).</p> <p>Results</p> <p>Verbal-fluency and Stroop-interference (left frontal and fronto-cingulate function) were negatively associated with noradrenergic turnover in nonparanoid and thought-disordered patients. High dopamine turnover related to speeded trail-making (frontal modulation of set switching) in those with many ideas-of-reference. In contrast, low dopamine turnover predicted poor recall in nonparanoid patients and those with little thought disorder. Serotonin metabolism did not independently contribute to the prediction any measure of cognitive performance. But, with regard to the relative activity between monoaminergic systems, increased HVA/5-HIAA ratios predicted visual-reproduction and Mooney's face-recognition performance (right-hemisphere functions) in highly symptomatic patients. Decreased HVA/MHPG predicted non-verbal recall.</p> <p>Conclusion</p> <p>Clinical state and function are differentially sensitive to overall levels of monoamine activity. In particular, right-lateralised cerebral function was sensitive to the relative activities of the monoamines. Increased noradrenergic activity was associated with enhanced frontal but impaired temporal lobe function in nonparanoid syndromes. Low dopaminergic activity predicted poor attentional set control in those with ideas-of-reference, but poor recall in nonparanoid patients. These data, especially the HVA/5-HIAA ratios, provide a basis for planning the nature of antipsychotic treatment aimed at patient specific symptom dimensions and cognitive abilities.</p> http://www.behavioralandbrainfunctions.com/content/1/1/14schizophreniacognitiondisorganisedideas of referenceparanoiddopaminenoradrenalineserotonin
collection DOAJ
language English
format Article
sources DOAJ
author Henning Uwe
Röpcke Bernd
Oades Robert D
Klimke Ansgard
spellingShingle Henning Uwe
Röpcke Bernd
Oades Robert D
Klimke Ansgard
Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
Behavioral and Brain Functions
schizophrenia
cognition
disorganised
ideas of reference
paranoid
dopamine
noradrenaline
serotonin
author_facet Henning Uwe
Röpcke Bernd
Oades Robert D
Klimke Ansgard
author_sort Henning Uwe
title Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
title_short Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
title_full Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
title_fullStr Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
title_full_unstemmed Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
title_sort neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity
publisher BMC
series Behavioral and Brain Functions
issn 1744-9081
publishDate 2005-08-01
description <p>Abstract</p> <p>Background</p> <p>Some clinical symptoms or cognitive functions have been related to the overall state of monoamine activity in patients with schizophrenia, (e.g. inverse correlation of the dopamine metabolite HVA with delusions or visual-masking performance). However, profiles (as presented here) of the relations of the activity of dopamine, noradrenaline and serotonin to neuropsychologic (dys)functions in major patient sub-groups with their very different symptomatic and cognitive characteristics have not been reported.</p> <p>Methods</p> <p>Serum measures of dopamine, noradrenaline and serotonin turnover were examined by regression analyses for the prediction of performance on 10 neuropsychological measures reflecting left- and right-hemispheric and frontal-, parietal- and temporal-lobe function in 108 patients with schizophrenia and 63 matched controls. The neuropsychological battery included tests of verbal fluency, Stroop interference, trail-making, block-design, Mooney faces recognition, picture-completion, immediate and delayed visual and verbal recall. Paranoid and nonparanoid subgroups were based on ratings from the Positive and Negative Syndrome Scale (PANSS). Groups with high and low ratings of ideas-of-reference and thought-disorder were formed from a median split on the Scale for Assessment of Positive Symptoms (SAPS).</p> <p>Results</p> <p>Verbal-fluency and Stroop-interference (left frontal and fronto-cingulate function) were negatively associated with noradrenergic turnover in nonparanoid and thought-disordered patients. High dopamine turnover related to speeded trail-making (frontal modulation of set switching) in those with many ideas-of-reference. In contrast, low dopamine turnover predicted poor recall in nonparanoid patients and those with little thought disorder. Serotonin metabolism did not independently contribute to the prediction any measure of cognitive performance. But, with regard to the relative activity between monoaminergic systems, increased HVA/5-HIAA ratios predicted visual-reproduction and Mooney's face-recognition performance (right-hemisphere functions) in highly symptomatic patients. Decreased HVA/MHPG predicted non-verbal recall.</p> <p>Conclusion</p> <p>Clinical state and function are differentially sensitive to overall levels of monoamine activity. In particular, right-lateralised cerebral function was sensitive to the relative activities of the monoamines. Increased noradrenergic activity was associated with enhanced frontal but impaired temporal lobe function in nonparanoid syndromes. Low dopaminergic activity predicted poor attentional set control in those with ideas-of-reference, but poor recall in nonparanoid patients. These data, especially the HVA/5-HIAA ratios, provide a basis for planning the nature of antipsychotic treatment aimed at patient specific symptom dimensions and cognitive abilities.</p>
topic schizophrenia
cognition
disorganised
ideas of reference
paranoid
dopamine
noradrenaline
serotonin
url http://www.behavioralandbrainfunctions.com/content/1/1/14
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