Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease
Background: Parkinson’s disease (PD) is a common neurodegenerative disease associated with progressive gray matter atrophy. In addition to motor function disorder, frailty and decreased muscle mass potentially contribute to increased morbidity risk. Objective: This study aimed to investiga...
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doaj-3620e93ee3d34af19a3b5f12dfc51afc2020-11-25T01:47:08ZengMDPI AGJournal of Clinical Medicine2077-03832020-01-019123910.3390/jcm9010239jcm9010239Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s DiseaseYing-Nong Wu0Meng-Hsiang Chen1Pi-Ling Chiang2Cheng-Hsien Lu3Hsiu-Ling Chen4Chiun-Chieh Yu5Yueh-Sheng Chen6Yung-Yee Chang7Wei-Che Lin8Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 83305, TaiwanBackground: Parkinson’s disease (PD) is a common neurodegenerative disease associated with progressive gray matter atrophy. In addition to motor function disorder, frailty and decreased muscle mass potentially contribute to increased morbidity risk. Objective: This study aimed to investigate the associations between lean muscle loss and gray matter volume (GMV) in PD patients. Methods: Thirty patients with PD and fifteen healthy controls underwent brain and bilateral thigh MRIs. The IDEAL sequence was employed, measuring the regions of interest (ROI) of fat percentage at the 50% point of femur length. Voxel-base morphometry (VBM) was used to assess regional gray matter volume differences between groups. Further correlation analysis was performed to evaluate the changes between gray matter volume and fatty percentage of the bilateral thigh after adjusting for age and gender. Multiple linear regression analysis was applied to evaluate the risk factor of core muscle loss in PD patients. Results: Compared with controls, patients with PD had significantly higher thigh fat percentage and smaller gray matter volume of several brain locations of the default mode network (DMN), specifically the left superior temporal gyrus, right uncus, and left inferior temporal gyrus, revealing association with higher thigh fat percentage. Further multiple linear regression analysis indicated that higher thigh fat percentage is associated with gender (female), increased disease duration, and smaller gray matter volume of the left superior temporal gyrus and right uncus in PD patients. Conclusions: Patients with PD experience core muscle loss in the thigh, associated with default mode network (DMN) degeneration, longer disease duration, and female gender. Identification of risk factors associated with lean muscle mass loss may assist in early prevention of comorbidities such as sarcopenia.https://www.mdpi.com/2077-0383/9/1/239gray mattermuscle atrophyneurodegenerative disorderparkinson’s diseasevoxel-based morphometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying-Nong Wu Meng-Hsiang Chen Pi-Ling Chiang Cheng-Hsien Lu Hsiu-Ling Chen Chiun-Chieh Yu Yueh-Sheng Chen Yung-Yee Chang Wei-Che Lin |
spellingShingle |
Ying-Nong Wu Meng-Hsiang Chen Pi-Ling Chiang Cheng-Hsien Lu Hsiu-Ling Chen Chiun-Chieh Yu Yueh-Sheng Chen Yung-Yee Chang Wei-Che Lin Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease Journal of Clinical Medicine gray matter muscle atrophy neurodegenerative disorder parkinson’s disease voxel-based morphometry |
author_facet |
Ying-Nong Wu Meng-Hsiang Chen Pi-Ling Chiang Cheng-Hsien Lu Hsiu-Ling Chen Chiun-Chieh Yu Yueh-Sheng Chen Yung-Yee Chang Wei-Che Lin |
author_sort |
Ying-Nong Wu |
title |
Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease |
title_short |
Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease |
title_full |
Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease |
title_fullStr |
Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease |
title_full_unstemmed |
Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson’s Disease |
title_sort |
associations between brain structural damage and core muscle loss in patients with parkinson’s disease |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-01-01 |
description |
Background: Parkinson’s disease (PD) is a common neurodegenerative disease associated with progressive gray matter atrophy. In addition to motor function disorder, frailty and decreased muscle mass potentially contribute to increased morbidity risk. Objective: This study aimed to investigate the associations between lean muscle loss and gray matter volume (GMV) in PD patients. Methods: Thirty patients with PD and fifteen healthy controls underwent brain and bilateral thigh MRIs. The IDEAL sequence was employed, measuring the regions of interest (ROI) of fat percentage at the 50% point of femur length. Voxel-base morphometry (VBM) was used to assess regional gray matter volume differences between groups. Further correlation analysis was performed to evaluate the changes between gray matter volume and fatty percentage of the bilateral thigh after adjusting for age and gender. Multiple linear regression analysis was applied to evaluate the risk factor of core muscle loss in PD patients. Results: Compared with controls, patients with PD had significantly higher thigh fat percentage and smaller gray matter volume of several brain locations of the default mode network (DMN), specifically the left superior temporal gyrus, right uncus, and left inferior temporal gyrus, revealing association with higher thigh fat percentage. Further multiple linear regression analysis indicated that higher thigh fat percentage is associated with gender (female), increased disease duration, and smaller gray matter volume of the left superior temporal gyrus and right uncus in PD patients. Conclusions: Patients with PD experience core muscle loss in the thigh, associated with default mode network (DMN) degeneration, longer disease duration, and female gender. Identification of risk factors associated with lean muscle mass loss may assist in early prevention of comorbidities such as sarcopenia. |
topic |
gray matter muscle atrophy neurodegenerative disorder parkinson’s disease voxel-based morphometry |
url |
https://www.mdpi.com/2077-0383/9/1/239 |
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