Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications
Gold/chitosan nanocomposites were synthesized and evaluated as a therapeutic agent for the photothermal therapy. Gold nanoparticles (Au NPs) with controllable optical absorption in the near infrared (NIR) region were prepared by the reaction of chloroauric acid and sodium thiosulfate. To apply these...
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doaj-3622f12aa19a4f5998a952078aec5f5f2020-11-24T23:16:55ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292012-01-01201210.1155/2012/853416853416Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy ApplicationsGuandong Zhang0Xinghua Sun1Jacek Jasinski2Dhruvin Patel3Andre M. Gobin4Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USADepartment of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USAConn Center for Renewable Energy Research and Speed School of Engineering, University of Louisville, Louisville, KY 40292, USADepartment of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USADepartment of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USAGold/chitosan nanocomposites were synthesized and evaluated as a therapeutic agent for the photothermal therapy. Gold nanoparticles (Au NPs) with controllable optical absorption in the near infrared (NIR) region were prepared by the reaction of chloroauric acid and sodium thiosulfate. To apply these particles to cancer therapy, the bare Au NPs were coated with chitosan (CS), O-carboxymethyl chitosan (CMCS), and a blend of CS and CMCS for utilizations in physiologic conditions. The surface properties, optical stability, and photothermal ablation efficiency on hepatocellular carcinoma cells (HepG2) and human dermal fibroblast cells (HDF) demonstrate that these gold nanocomposites have great potential as a therapeutic agent in in vitro tests. The CS-coated nanocomposites show the highest efficiency for the photo-ablation on the HepG2 cells, and the CS and CMCS blended coated particles show the best discrimination between the cancer cell and normal cells. The well-controlled NIR absorption and the biocompatible surface of these nanocomposites allow low-power NIR laser activation and low-dosage particle injection for the cancer cell treatment.http://dx.doi.org/10.1155/2012/853416 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guandong Zhang Xinghua Sun Jacek Jasinski Dhruvin Patel Andre M. Gobin |
spellingShingle |
Guandong Zhang Xinghua Sun Jacek Jasinski Dhruvin Patel Andre M. Gobin Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications Journal of Nanomaterials |
author_facet |
Guandong Zhang Xinghua Sun Jacek Jasinski Dhruvin Patel Andre M. Gobin |
author_sort |
Guandong Zhang |
title |
Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications |
title_short |
Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications |
title_full |
Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications |
title_fullStr |
Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications |
title_full_unstemmed |
Gold/Chitosan Nanocomposites with Specific Near Infrared Absorption for Photothermal Therapy Applications |
title_sort |
gold/chitosan nanocomposites with specific near infrared absorption for photothermal therapy applications |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2012-01-01 |
description |
Gold/chitosan nanocomposites were synthesized and evaluated as a therapeutic agent for the photothermal therapy. Gold nanoparticles (Au NPs) with controllable optical absorption in the near infrared (NIR) region were prepared by the reaction of chloroauric acid and sodium thiosulfate. To apply these particles to cancer therapy, the bare Au NPs were coated with chitosan (CS), O-carboxymethyl chitosan (CMCS), and a blend of CS and CMCS for utilizations in physiologic conditions. The surface properties, optical stability, and photothermal ablation efficiency on hepatocellular carcinoma cells (HepG2) and human dermal fibroblast cells (HDF) demonstrate that these gold nanocomposites have great potential as a therapeutic agent in in vitro tests. The CS-coated nanocomposites show the highest efficiency for the photo-ablation on the HepG2 cells, and the CS and CMCS blended coated particles show the best discrimination between the cancer cell and normal cells. The well-controlled NIR absorption and the biocompatible surface of these nanocomposites allow low-power NIR laser activation and low-dosage particle injection for the cancer cell treatment. |
url |
http://dx.doi.org/10.1155/2012/853416 |
work_keys_str_mv |
AT guandongzhang goldchitosannanocompositeswithspecificnearinfraredabsorptionforphotothermaltherapyapplications AT xinghuasun goldchitosannanocompositeswithspecificnearinfraredabsorptionforphotothermaltherapyapplications AT jacekjasinski goldchitosannanocompositeswithspecificnearinfraredabsorptionforphotothermaltherapyapplications AT dhruvinpatel goldchitosannanocompositeswithspecificnearinfraredabsorptionforphotothermaltherapyapplications AT andremgobin goldchitosannanocompositeswithspecificnearinfraredabsorptionforphotothermaltherapyapplications |
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