Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial
Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on t...
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doaj-3625f132af614a37b380f203f30917462020-11-25T02:04:49ZengMDPI AGNutrients2072-66432020-03-0112386110.3390/nu12030861nu12030861Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical TrialSaloni Brahmbhatt0Mageda Mikhail1Shahidul Islam2John F. Aloia3Bone Mineral Research, NYU Winthrop Hospital/NYU Langone Health, Mineola, NY 11501, USADepartment of Endocrinology, NYU Winthrop Hospital/NYU Langone Health, Mineola, NY 11501, USABiostatistician, NYU Winthrop Research Institute, NYU Long Island School of Medicine, NYU Langone Health, Mineola, NY 11501, USABone Mineral Research, NYU Winthrop Hospital/NYU Langone Health, Mineola, NY 11501, USAAbdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group.https://www.mdpi.com/2072-6643/12/3/861abdominal aortic calcification (aac)extended aortic calcification (aac24)chronic kidney disease (ckd)vertebral fracture assessment (vfa)vascular calcification (vc)dual-energy x-ray absorptiometry (dxa)african american (aa)parathyroid hormone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saloni Brahmbhatt Mageda Mikhail Shahidul Islam John F. Aloia |
spellingShingle |
Saloni Brahmbhatt Mageda Mikhail Shahidul Islam John F. Aloia Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial Nutrients abdominal aortic calcification (aac) extended aortic calcification (aac24) chronic kidney disease (ckd) vertebral fracture assessment (vfa) vascular calcification (vc) dual-energy x-ray absorptiometry (dxa) african american (aa) parathyroid hormone |
author_facet |
Saloni Brahmbhatt Mageda Mikhail Shahidul Islam John F. Aloia |
author_sort |
Saloni Brahmbhatt |
title |
Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial |
title_short |
Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial |
title_full |
Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial |
title_fullStr |
Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial |
title_full_unstemmed |
Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial |
title_sort |
vitamin d and abdominal aortic calcification in older african american women, the poda clinical trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-03-01 |
description |
Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group. |
topic |
abdominal aortic calcification (aac) extended aortic calcification (aac24) chronic kidney disease (ckd) vertebral fracture assessment (vfa) vascular calcification (vc) dual-energy x-ray absorptiometry (dxa) african american (aa) parathyroid hormone |
url |
https://www.mdpi.com/2072-6643/12/3/861 |
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