Promoter Motifs in NCLDVs: An Evolutionary Perspective
For many years, gene expression in the three cellular domains has been studied in an attempt to discover sequences associated with the regulation of the transcription process. Some specific transcriptional features were described in viruses, although few studies have been devoted to understanding th...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-01-01
|
Series: | Viruses |
Subjects: | |
Online Access: | http://www.mdpi.com/1999-4915/9/1/16 |
id |
doaj-362a0389646248869bec1c3b8131cc8d |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Graziele Pereira Oliveira Ana Cláudia dos Santos Pereira Andrade Rodrigo Araújo Lima Rodrigues Thalita Souza Arantes Paulo Victor Miranda Boratto Ludmila Karen dos Santos Silva Fábio Pio Dornas Giliane de Souza Trindade Betânia Paiva Drumond Bernard La Scola Erna Geessien Kroon Jônatas Santos Abrahão |
spellingShingle |
Graziele Pereira Oliveira Ana Cláudia dos Santos Pereira Andrade Rodrigo Araújo Lima Rodrigues Thalita Souza Arantes Paulo Victor Miranda Boratto Ludmila Karen dos Santos Silva Fábio Pio Dornas Giliane de Souza Trindade Betânia Paiva Drumond Bernard La Scola Erna Geessien Kroon Jônatas Santos Abrahão Promoter Motifs in NCLDVs: An Evolutionary Perspective Viruses megavirales NCLDV giant viruses promoter transcription evolution MEGA-box |
author_facet |
Graziele Pereira Oliveira Ana Cláudia dos Santos Pereira Andrade Rodrigo Araújo Lima Rodrigues Thalita Souza Arantes Paulo Victor Miranda Boratto Ludmila Karen dos Santos Silva Fábio Pio Dornas Giliane de Souza Trindade Betânia Paiva Drumond Bernard La Scola Erna Geessien Kroon Jônatas Santos Abrahão |
author_sort |
Graziele Pereira Oliveira |
title |
Promoter Motifs in NCLDVs: An Evolutionary Perspective |
title_short |
Promoter Motifs in NCLDVs: An Evolutionary Perspective |
title_full |
Promoter Motifs in NCLDVs: An Evolutionary Perspective |
title_fullStr |
Promoter Motifs in NCLDVs: An Evolutionary Perspective |
title_full_unstemmed |
Promoter Motifs in NCLDVs: An Evolutionary Perspective |
title_sort |
promoter motifs in ncldvs: an evolutionary perspective |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2017-01-01 |
description |
For many years, gene expression in the three cellular domains has been studied in an attempt to discover sequences associated with the regulation of the transcription process. Some specific transcriptional features were described in viruses, although few studies have been devoted to understanding the evolutionary aspects related to the spread of promoter motifs through related viral families. The discovery of giant viruses and the proposition of the new viral order Megavirales that comprise a monophyletic group, named nucleo-cytoplasmic large DNA viruses (NCLDV), raised new questions in the field. Some putative promoter sequences have already been described for some NCLDV members, bringing new insights into the evolutionary history of these complex microorganisms. In this review, we summarize the main aspects of the transcription regulation process in the three domains of life, followed by a systematic description of what is currently known about promoter regions in several NCLDVs. We also discuss how the analysis of the promoter sequences could bring new ideas about the giant viruses’ evolution. Finally, considering a possible common ancestor for the NCLDV group, we discussed possible promoters’ evolutionary scenarios and propose the term “MEGA-box” to designate an ancestor promoter motif (‘TATATAAAATTGA’) that could be evolved gradually by nucleotides’ gain and loss and point mutations. |
topic |
megavirales NCLDV giant viruses promoter transcription evolution MEGA-box |
url |
http://www.mdpi.com/1999-4915/9/1/16 |
work_keys_str_mv |
AT grazielepereiraoliveira promotermotifsinncldvsanevolutionaryperspective AT anaclaudiadossantospereiraandrade promotermotifsinncldvsanevolutionaryperspective AT rodrigoaraujolimarodrigues promotermotifsinncldvsanevolutionaryperspective AT thalitasouzaarantes promotermotifsinncldvsanevolutionaryperspective AT paulovictormirandaboratto promotermotifsinncldvsanevolutionaryperspective AT ludmilakarendossantossilva promotermotifsinncldvsanevolutionaryperspective AT fabiopiodornas promotermotifsinncldvsanevolutionaryperspective AT gilianedesouzatrindade promotermotifsinncldvsanevolutionaryperspective AT betaniapaivadrumond promotermotifsinncldvsanevolutionaryperspective AT bernardlascola promotermotifsinncldvsanevolutionaryperspective AT ernageessienkroon promotermotifsinncldvsanevolutionaryperspective AT jonatassantosabrahao promotermotifsinncldvsanevolutionaryperspective |
_version_ |
1725562469973229568 |
spelling |
doaj-362a0389646248869bec1c3b8131cc8d2020-11-24T23:24:00ZengMDPI AGViruses1999-49152017-01-01911610.3390/v9010016v9010016Promoter Motifs in NCLDVs: An Evolutionary PerspectiveGraziele Pereira Oliveira0Ana Cláudia dos Santos Pereira Andrade1Rodrigo Araújo Lima Rodrigues2Thalita Souza Arantes3Paulo Victor Miranda Boratto4Ludmila Karen dos Santos Silva5Fábio Pio Dornas6Giliane de Souza Trindade7Betânia Paiva Drumond8Bernard La Scola9Erna Geessien Kroon10Jônatas Santos Abrahão11Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilUnité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Université., 27 Boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, FranceLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilLaboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, BrazilFor many years, gene expression in the three cellular domains has been studied in an attempt to discover sequences associated with the regulation of the transcription process. Some specific transcriptional features were described in viruses, although few studies have been devoted to understanding the evolutionary aspects related to the spread of promoter motifs through related viral families. The discovery of giant viruses and the proposition of the new viral order Megavirales that comprise a monophyletic group, named nucleo-cytoplasmic large DNA viruses (NCLDV), raised new questions in the field. Some putative promoter sequences have already been described for some NCLDV members, bringing new insights into the evolutionary history of these complex microorganisms. In this review, we summarize the main aspects of the transcription regulation process in the three domains of life, followed by a systematic description of what is currently known about promoter regions in several NCLDVs. We also discuss how the analysis of the promoter sequences could bring new ideas about the giant viruses’ evolution. Finally, considering a possible common ancestor for the NCLDV group, we discussed possible promoters’ evolutionary scenarios and propose the term “MEGA-box” to designate an ancestor promoter motif (‘TATATAAAATTGA’) that could be evolved gradually by nucleotides’ gain and loss and point mutations.http://www.mdpi.com/1999-4915/9/1/16megaviralesNCLDVgiant virusespromotertranscriptionevolutionMEGA-box |