IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

IgSF9b is a synaptic adhesion protein that has been linked to psychiatric disorders. Here the authors show that deletion of IgSF9b regulates anxiety-like behaviour in mice by increasing inhibitory synaptic transmission in the centromedial amygdala.

Bibliographic Details
Main Authors:	Olga Babaev, Hugo Cruces-Solis, Carolina Piletti Chatain, Matthieu Hammer, Sally Wenger, Heba Ali, Nikolaos Karalis, Livia de Hoz, Oliver M. Schlüter, Yuchio Yanagawa, Hannelore Ehrenreich, Holger Taschenberger, Nils Brose, Dilja Krueger-Burg
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07762-1

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spelling	doaj-362f3b269d1245b2923fe26c721003ee2021-05-11T10:08:46ZengNature Publishing GroupNature Communications2041-17232018-12-019111610.1038/s41467-018-07762-1IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapsesOlga Babaev0Hugo Cruces-Solis1Carolina Piletti Chatain2Matthieu Hammer3Sally Wenger4Heba Ali5Nikolaos Karalis6Livia de Hoz7Oliver M. Schlüter8Yuchio Yanagawa9Hannelore Ehrenreich10Holger Taschenberger11Nils Brose12Dilja Krueger-Burg13Department of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineFriedrich Miescher Institute for Biomedical ResearchDepartment of Neurogenetics, Max Planck Institute of Experimental MedicineEuropean Neuroscience Institute GöttingenDepartment of Genetic and Behavioral Neuroscience, Gunma University Graduate School of MedicineClinical Neuroscience, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineDepartment of Molecular Neurobiology, Max Planck Institute of Experimental MedicineIgSF9b is a synaptic adhesion protein that has been linked to psychiatric disorders. Here the authors show that deletion of IgSF9b regulates anxiety-like behaviour in mice by increasing inhibitory synaptic transmission in the centromedial amygdala.https://doi.org/10.1038/s41467-018-07762-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Olga Babaev Hugo Cruces-Solis Carolina Piletti Chatain Matthieu Hammer Sally Wenger Heba Ali Nikolaos Karalis Livia de Hoz Oliver M. Schlüter Yuchio Yanagawa Hannelore Ehrenreich Holger Taschenberger Nils Brose Dilja Krueger-Burg
spellingShingle	Olga Babaev Hugo Cruces-Solis Carolina Piletti Chatain Matthieu Hammer Sally Wenger Heba Ali Nikolaos Karalis Livia de Hoz Oliver M. Schlüter Yuchio Yanagawa Hannelore Ehrenreich Holger Taschenberger Nils Brose Dilja Krueger-Burg IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses Nature Communications
author_facet	Olga Babaev Hugo Cruces-Solis Carolina Piletti Chatain Matthieu Hammer Sally Wenger Heba Ali Nikolaos Karalis Livia de Hoz Oliver M. Schlüter Yuchio Yanagawa Hannelore Ehrenreich Holger Taschenberger Nils Brose Dilja Krueger-Burg
author_sort	Olga Babaev
title	IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
title_short	IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
title_full	IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
title_fullStr	IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
title_full_unstemmed	IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
title_sort	igsf9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-12-01
description	IgSF9b is a synaptic adhesion protein that has been linked to psychiatric disorders. Here the authors show that deletion of IgSF9b regulates anxiety-like behaviour in mice by increasing inhibitory synaptic transmission in the centromedial amygdala.
url	https://doi.org/10.1038/s41467-018-07762-1
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IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

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