The importance of anti peroxidase antibodies in patients with nodular thyroid goiter

• Main Authors: Medenica Sanja, Trbojević Božo
• Format: Article
• Language: English
• Published: Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor 2012-01-01
• Series: Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"
• Subjects: thyroid nodule; anti peroxidase antibodies; thyroid autoimmunity; fine needle aspiration
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2012/1452-09231245007M.pdf

Introduction: Thyroid nodular goiter Nodular goiter is clinically recognizable restricted structure changes of the thyroid gland. Numerous studies show the relationship between thyroid autoimmunity and differentiated thyroid cancer in patients with nodular thyroid goiter. One of the important clinical marker in defining thyroid autoimmunity are antibodies to thyroid peroxidase. Objective: The aim of this study was to analyze the relationship between antibodies anti peroksidaznih ii thyroid malignancies in patients with thyroid altered thyroid. Material and Methods: We retrospectively reviewed the 248 reports of thyroid FNA cytology of samples obtained by puncture of patients with nodular thyroid goiter, at Department of thyroid gland, Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia in the period from October 2007. by January 2010. year. We analyzed the relationship between findings of cytopathological diagnostic categories and serum concentrations of anti peroxidase antibodies. The data were statistically processed using the computer program SPSS 12.0 software package. Results: Of total 248 patients, 148 patients (59.7%) had anti-TPO antibody values in a reference limits (30 IU/ml), and 40.3% elevated anti-TPO antibodies (over 30 IU/ml). In the group of patients with elevated values of anti-TPO antibodies 7% (7/100) of patients had malignant cytologic findings, and in the group of patients with anti-TPO antibody values in the normal range only 1.4% (2/148) of patients had malignant cytologic findings. Conclusion: Defining the relationship between thyroid autoimmune disease and differentiated thyroid cancer, providing new insights in the field of immunotherapy of thyroid carcinoma. Enlightening the molecular mechanisms link autoimmune thyroid disease and thyroid cancer development in patients with thyroid nodule help find new therapeutic strategies against thyroid cancer.