Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative.
Higher body mass index (BMI) measured before endometrial cancer diagnosis has been associated with greater risk of developing endometrial cancer and higher mortality, but the association between BMI measured after diagnosis and mortality risk is unclear. We identified 467 women (91 deaths) in the Wo...
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doaj-365328f2eb264b9aa9c82319b960a2842020-11-25T01:59:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017125010.1371/journal.pone.0171250Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative.Hannah AremRuth M PfeifferSteven C MooreMelinda L IrwinMichael J LaMonteGloria E SartoRami NassirJuhua LuoRowan T ChlebowskiLouise A BrintonCharles E MatthewsHigher body mass index (BMI) measured before endometrial cancer diagnosis has been associated with greater risk of developing endometrial cancer and higher mortality, but the association between BMI measured after diagnosis and mortality risk is unclear. We identified 467 women (91 deaths) in the Women's Health Initiative (WHI) with information on BMI measured after diagnosis and used Cox proportional hazards regression to generate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality. Comparing BMI 35+ with <25 kg/m2, we observed no association with all-cause mortality (HR = 1.02, 95% CI 0.55-1.91). Our study does not support the hypothesis that higher BMI after endometrial cancer diagnosis is associated with poorer survival.http://europepmc.org/articles/PMC5289573?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hannah Arem Ruth M Pfeiffer Steven C Moore Melinda L Irwin Michael J LaMonte Gloria E Sarto Rami Nassir Juhua Luo Rowan T Chlebowski Louise A Brinton Charles E Matthews |
spellingShingle |
Hannah Arem Ruth M Pfeiffer Steven C Moore Melinda L Irwin Michael J LaMonte Gloria E Sarto Rami Nassir Juhua Luo Rowan T Chlebowski Louise A Brinton Charles E Matthews Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. PLoS ONE |
author_facet |
Hannah Arem Ruth M Pfeiffer Steven C Moore Melinda L Irwin Michael J LaMonte Gloria E Sarto Rami Nassir Juhua Luo Rowan T Chlebowski Louise A Brinton Charles E Matthews |
author_sort |
Hannah Arem |
title |
Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. |
title_short |
Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. |
title_full |
Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. |
title_fullStr |
Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. |
title_full_unstemmed |
Post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: Results from the Women's Health Initiative. |
title_sort |
post-diagnosis body mass index and mortality among women diagnosed with endometrial cancer: results from the women's health initiative. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
Higher body mass index (BMI) measured before endometrial cancer diagnosis has been associated with greater risk of developing endometrial cancer and higher mortality, but the association between BMI measured after diagnosis and mortality risk is unclear. We identified 467 women (91 deaths) in the Women's Health Initiative (WHI) with information on BMI measured after diagnosis and used Cox proportional hazards regression to generate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality. Comparing BMI 35+ with <25 kg/m2, we observed no association with all-cause mortality (HR = 1.02, 95% CI 0.55-1.91). Our study does not support the hypothesis that higher BMI after endometrial cancer diagnosis is associated with poorer survival. |
url |
http://europepmc.org/articles/PMC5289573?pdf=render |
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