Epigenetic therapy combinations in acute myeloid leukemia: what are the options?

Epigenetic therapy combinations in acute myeloid leukemia: what are the options?

Epigenetics refers to the regulation of gene expression mainly by changes in DNA methylation and modifications of histone proteins without altering the actual DNA sequence. While epigenetic modifications are essential for normal cell differentiation, several driver mutations in leukemic pathogenesis...

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Bibliographic Details
Main Authors: Jan Philipp Bewersdorf, Rory Shallis, Maximilian Stahl, Amer M. Zeidan
Format: Article
Language:English
Published: SAGE Publishing 2019-01-01
Series:Therapeutic Advances in Hematology
Online Access:https://doi.org/10.1177/2040620718816698

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