The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks
Potential molecular alterations based on age and sex are not well defined in diffuse large B-cell lymphoma (DLBCL). We examined global transcriptome DLBCL data from The Cancer Genome Atlas (TCGA) via a systems biology approach to determine the molecular differences associated with age and sex. Colle...
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doaj-365c3e651c95481188c033b114205c222020-11-25T03:24:36ZengSAGE PublishingCancer Informatics1176-93512015-01-011410.4137/CIN.S34144The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling NetworksAfshin Beheshti0Donna Neuberg1J. Tyson Mcdonald2Charles R. Vanderburg3Andrew M. Evens4Division of Hematology/Oncology, Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, USA.Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard University, Boston, MA, USA.Cancer Research Center, Hampton University, Hampton, VA, USA.Harvard NeuroDiscovery Center, Massachusetts General Hospital, Boston, MA, USA.Tufts University School of Medicine, Boston, MA, USA.Potential molecular alterations based on age and sex are not well defined in diffuse large B-cell lymphoma (DLBCL). We examined global transcriptome DLBCL data from The Cancer Genome Atlas (TCGA) via a systems biology approach to determine the molecular differences associated with age and sex. Collectively, sex and age revealed striking transcriptional differences with older age associated with decreased metabolism and telomere functions and female sex was associated with decreased interferon signaling, transcription, cell cycle, and PD-1 signaling. We discovered that the key genes for most groups strongly regulated immune function activity. Furthermore, older females were predicted to have less DLBCL progression versus older males and young females. Finally, analyses in systems biology revealed that JUN and CYCS signaling were the most critical factors associated with tumor progression in older and male patients. We identified important molecular perturbations in DLBCL that were strongly associated with age and sex and were predicted to strongly influence tumor progression.https://doi.org/10.4137/CIN.S34144 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Afshin Beheshti Donna Neuberg J. Tyson Mcdonald Charles R. Vanderburg Andrew M. Evens |
spellingShingle |
Afshin Beheshti Donna Neuberg J. Tyson Mcdonald Charles R. Vanderburg Andrew M. Evens The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks Cancer Informatics |
author_facet |
Afshin Beheshti Donna Neuberg J. Tyson Mcdonald Charles R. Vanderburg Andrew M. Evens |
author_sort |
Afshin Beheshti |
title |
The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks |
title_short |
The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks |
title_full |
The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks |
title_fullStr |
The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks |
title_full_unstemmed |
The Impact of Age and Sex in DLBCL: Systems Biology Analyses Identify Distinct Molecular Changes and Signaling Networks |
title_sort |
impact of age and sex in dlbcl: systems biology analyses identify distinct molecular changes and signaling networks |
publisher |
SAGE Publishing |
series |
Cancer Informatics |
issn |
1176-9351 |
publishDate |
2015-01-01 |
description |
Potential molecular alterations based on age and sex are not well defined in diffuse large B-cell lymphoma (DLBCL). We examined global transcriptome DLBCL data from The Cancer Genome Atlas (TCGA) via a systems biology approach to determine the molecular differences associated with age and sex. Collectively, sex and age revealed striking transcriptional differences with older age associated with decreased metabolism and telomere functions and female sex was associated with decreased interferon signaling, transcription, cell cycle, and PD-1 signaling. We discovered that the key genes for most groups strongly regulated immune function activity. Furthermore, older females were predicted to have less DLBCL progression versus older males and young females. Finally, analyses in systems biology revealed that JUN and CYCS signaling were the most critical factors associated with tumor progression in older and male patients. We identified important molecular perturbations in DLBCL that were strongly associated with age and sex and were predicted to strongly influence tumor progression. |
url |
https://doi.org/10.4137/CIN.S34144 |
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