Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice
High blood pressure: Exploring inheritance A propensity towards high blood pressure may be passed down through several generations from adults who were born preterm. People who are born prematurely often suffer from kidney (renal) problems, high blood pressure and cardiovascular disease as they age....
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2020-01-01
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Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-020-0373-5 |
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doaj-365e4d27f9cd4d4e98be952ee278defc2021-01-24T12:42:30ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-01-0152115216510.1038/s12276-020-0373-5Preterm birth is associated with epigenetic programming of transgenerational hypertension in miceLaurence Dumeige0Mélanie Nehlich1Say Viengchareun2Julie Perrot3Eric Pussard4Marc Lombès5Laetitia Martinerie6Inserm U1185Inserm U1185Inserm U1185Inserm U1185Inserm U1185Inserm U1185Inserm U1185High blood pressure: Exploring inheritance A propensity towards high blood pressure may be passed down through several generations from adults who were born preterm. People who are born prematurely often suffer from kidney (renal) problems, high blood pressure and cardiovascular disease as they age. Recent research suggests adults born prematurely can pass dysregulated blood pressure to their children. Laetitia Martinerie at INSERM Unit 1185, Le Kremlin Bicêtre and Robert Debré Hospital in Paris, France, and co-workers studied generations of mice to explore how epigenetic alterations, DNA modifications that do not change the DNA code, affect blood pressure from birth through to adulthood. The team identified tissue-specific alterations in renal signaling pathways in premature mice. They also traced the associated overexpression of a gene called Gilz, known to play a role in blood pressure maintenance, through second and third generation mice born to the first generation preterms.https://doi.org/10.1038/s12276-020-0373-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laurence Dumeige Mélanie Nehlich Say Viengchareun Julie Perrot Eric Pussard Marc Lombès Laetitia Martinerie |
spellingShingle |
Laurence Dumeige Mélanie Nehlich Say Viengchareun Julie Perrot Eric Pussard Marc Lombès Laetitia Martinerie Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice Experimental and Molecular Medicine |
author_facet |
Laurence Dumeige Mélanie Nehlich Say Viengchareun Julie Perrot Eric Pussard Marc Lombès Laetitia Martinerie |
author_sort |
Laurence Dumeige |
title |
Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice |
title_short |
Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice |
title_full |
Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice |
title_fullStr |
Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice |
title_full_unstemmed |
Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice |
title_sort |
preterm birth is associated with epigenetic programming of transgenerational hypertension in mice |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2020-01-01 |
description |
High blood pressure: Exploring inheritance A propensity towards high blood pressure may be passed down through several generations from adults who were born preterm. People who are born prematurely often suffer from kidney (renal) problems, high blood pressure and cardiovascular disease as they age. Recent research suggests adults born prematurely can pass dysregulated blood pressure to their children. Laetitia Martinerie at INSERM Unit 1185, Le Kremlin Bicêtre and Robert Debré Hospital in Paris, France, and co-workers studied generations of mice to explore how epigenetic alterations, DNA modifications that do not change the DNA code, affect blood pressure from birth through to adulthood. The team identified tissue-specific alterations in renal signaling pathways in premature mice. They also traced the associated overexpression of a gene called Gilz, known to play a role in blood pressure maintenance, through second and third generation mice born to the first generation preterms. |
url |
https://doi.org/10.1038/s12276-020-0373-5 |
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