Explore a novel function of human condensins in cellular senescence

• Main Authors: Hongzhen Wang, Xin Liu, Guiying Li
• Format: Article
• Language: English
• Published: BMC 2020-12-01
• Series: Cell & Bioscience
• Subjects: Human condensins; Cellular senescence; Oncogene-induced senescence; Replicative senescence
• Online Access: https://doi.org/10.1186/s13578-020-00512-1

Abstract There are two kinds of condensins in human cells, known as condensin I and condensin II. The canonical roles of condensins are participated in chromosome dynamics, including chromosome condensation and segregation during cell division. Recently, a novel function of human condensins has been found with increasing evidences that they play important roles in cellular senescence. This paper reviewed the research progress of human condensins involved in different types of cellular senescence, mainly oncogene-induced senescence (OIS) and replicative senescence (RS). The future perspectives of human condensins involved in cellular senescence are also discussed.