Effects of aerobic training with coriander seed extract on serum paraoxonase-1, TNF-α, and CRP in diabetic rats

• Main Authors: Ahmad Abdi, zinab sheykholeslami, Azadeh Ghorbani hasan saraee, hajar abaszadeh, parvin farzanegi, zakie sheykholeslami
• Format: Article
• Language: fas
• Published: Neyshabur University of Medical Sciences 2018-05-01
• Series: Majallah-i Dānishkadah-i ̒ulūm-i Pizishkī-i Niyshābūr
• Subjects: exercise; coriander; vascular injury; inflammatory profile; Lipid profile
• Online Access: http://journal.nums.ac.ir/browse.php?a_code=A-10-428-2&slc_lang=en&sid=1

Introduction The main purpose of this study was to investigate the effects of aerobic training with coriander seed extract on serum paraoxonase-1, TNF-α, and CRP in diabetic rats. Materials and Methods 40 Diabetic male Wistar rats (8 weeks old; weight: 130 ± 10 g) were randomly divided into four groups: control, extract, training, and training-Extract. Diabetes was induced by using Streptozotocin. Rats were selected as diabetic, with fasting blood glucose 126-400 mg/dl. The extract was administered orally (150 mg/kg/day). The exercise program was six weeks, 5 times a week with 50-55% of maximal oxygen consumption. The data were analyzed using of one-way ANOVA and Tukey test at α<0.05. Results Aerobic training with coriander seed extract increased serum paraoxonase-1 (P = 0.000) and HDL (P = 0.000). It also decreased TNF-α (P = 0.017), CRP (P = 0.014),   TG (P = 0.007), TC (P = 0.029) and LDL (P = 0.012) in diabetic male rats. We, then applied, post hoc test, it showed that a significant difference between the groups at the level of this profile. Conclusion  Six weeks of regular aerobic training with coriander seed extract have been shown to increase paraoxonase-1 and decrease levels of TNF-α and CRP in diabetic rats, and possibly moderates the risk of atherosclerosis in type 2 diabetes.