The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla (PCCs) or extra-adrenal sympathetic or parasympathetic paraganglia (PGLs). About 40% of PPGLs result from germline mutations and therefore they are highly inheritable....

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Bibliographic Details
Main Authors: Song Peng, Jun Zhang, Xintao Tan, Yiqiang Huang, Jing Xu, Natalie Silk, Dianzheng Zhang, Qiuli Liu, Jun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Endocrinology
Subjects:
pheochromocytomas
paragangliomas
VHL
HIF
metabolism
inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.586857/full

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