Targeting the Resistance in Multiple Myeloma
Multiple myeloma is a hematological cancer characterized by the clonal proliferation of malignant plasma cells in the bone marrow. That disease has a rather low incidence but displays a high rate of relapse and resistance to conventional therapies. It is therefore necessary to find new therapeutic s...
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MDPI AG
2019-04-01
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| Series: | Proceedings |
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| Online Access: | https://www.mdpi.com/2504-3900/11/1/3 |
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doaj-368d1684736041999f5710d616a90adb2020-11-25T00:52:34ZengMDPI AGProceedings2504-39002019-04-01111310.3390/proceedings2019011003proceedings2019011003Targeting the Resistance in Multiple MyelomaMicaela Freitas0Mark E. IssaMuriel CuendetSchool of pharmaceutical sciences, University of Geneva, University of Lausanne, Rue Michel-Servet 1, 1211 Geneva, SwitzerlandMultiple myeloma is a hematological cancer characterized by the clonal proliferation of malignant plasma cells in the bone marrow. That disease has a rather low incidence but displays a high rate of relapse and resistance to conventional therapies. It is therefore necessary to find new therapeutic strategies to overcome this resistance, which is partly attributed to a subpopulation of cells known as cancer stem cells. Withanolides and HDAC6 selective inhibitors were identified as promising compounds in various resistant multiple myeloma models.https://www.mdpi.com/2504-3900/11/1/3multiple myeloma3D co-culture modelcancer resistance |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Micaela Freitas Mark E. Issa Muriel Cuendet |
| spellingShingle |
Micaela Freitas Mark E. Issa Muriel Cuendet Targeting the Resistance in Multiple Myeloma Proceedings multiple myeloma 3D co-culture model cancer resistance |
| author_facet |
Micaela Freitas Mark E. Issa Muriel Cuendet |
| author_sort |
Micaela Freitas |
| title |
Targeting the Resistance in Multiple Myeloma |
| title_short |
Targeting the Resistance in Multiple Myeloma |
| title_full |
Targeting the Resistance in Multiple Myeloma |
| title_fullStr |
Targeting the Resistance in Multiple Myeloma |
| title_full_unstemmed |
Targeting the Resistance in Multiple Myeloma |
| title_sort |
targeting the resistance in multiple myeloma |
| publisher |
MDPI AG |
| series |
Proceedings |
| issn |
2504-3900 |
| publishDate |
2019-04-01 |
| description |
Multiple myeloma is a hematological cancer characterized by the clonal proliferation of malignant plasma cells in the bone marrow. That disease has a rather low incidence but displays a high rate of relapse and resistance to conventional therapies. It is therefore necessary to find new therapeutic strategies to overcome this resistance, which is partly attributed to a subpopulation of cells known as cancer stem cells. Withanolides and HDAC6 selective inhibitors were identified as promising compounds in various resistant multiple myeloma models. |
| topic |
multiple myeloma 3D co-culture model cancer resistance |
| url |
https://www.mdpi.com/2504-3900/11/1/3 |
| work_keys_str_mv |
AT micaelafreitas targetingtheresistanceinmultiplemyeloma AT markeissa targetingtheresistanceinmultiplemyeloma AT murielcuendet targetingtheresistanceinmultiplemyeloma |
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