CPP-Assisted Intracellular Drug Delivery, What Is Next?
For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and pr...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2016-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/17/11/1892 |
id |
doaj-3695c8f62d314cbc84a3edba94c36803 |
---|---|
record_format |
Article |
spelling |
doaj-3695c8f62d314cbc84a3edba94c368032020-11-24T21:47:20ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-11-011711189210.3390/ijms17111892ijms17111892CPP-Assisted Intracellular Drug Delivery, What Is Next?Junxiao Ye0Ergang Liu1Zhili Yu2Xing Pei3Sunhui Chen4Pengwei Zhang5Meong-Cheol Shin6Junbo Gong7Huining He8Victor C. Yang9Collaborative Innovation Center of Chemical Science and Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaCollaborative Innovation Center of Chemical Science and Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory on Technologies Enabling, Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, ChinaTianjin Key Laboratory on Technologies Enabling, Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, ChinaTianjin Key Laboratory on Technologies Enabling, Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, ChinaCollaborative Innovation Center of Chemical Science and Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinjudaero, Jinju, Gyeongnam 660-751, KoreaCollaborative Innovation Center of Chemical Science and Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory on Technologies Enabling, Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, ChinaTianjin Key Laboratory on Technologies Enabling, Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, ChinaFor the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and proteins into cells, thereby denying their clinical potential to become potent anti-cancer drugs. By taking the advantage of the unique cell-translocation property of these short peptides, various payloads of proteins, nucleic acids, or even nanoparticle-based carriers were delivered into all cell types with unparalleled efficiency. However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects. In view of these challenges, we present herein a review of the new designs of CPP-linked vehicles and strategies to achieve highly effective yet less toxic chemotherapy in combating tumor oncology.http://www.mdpi.com/1422-0067/17/11/1892CPPsintracellular deliverypH and enzyme triggered drug delivery system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junxiao Ye Ergang Liu Zhili Yu Xing Pei Sunhui Chen Pengwei Zhang Meong-Cheol Shin Junbo Gong Huining He Victor C. Yang |
spellingShingle |
Junxiao Ye Ergang Liu Zhili Yu Xing Pei Sunhui Chen Pengwei Zhang Meong-Cheol Shin Junbo Gong Huining He Victor C. Yang CPP-Assisted Intracellular Drug Delivery, What Is Next? International Journal of Molecular Sciences CPPs intracellular delivery pH and enzyme triggered drug delivery system |
author_facet |
Junxiao Ye Ergang Liu Zhili Yu Xing Pei Sunhui Chen Pengwei Zhang Meong-Cheol Shin Junbo Gong Huining He Victor C. Yang |
author_sort |
Junxiao Ye |
title |
CPP-Assisted Intracellular Drug Delivery, What Is Next? |
title_short |
CPP-Assisted Intracellular Drug Delivery, What Is Next? |
title_full |
CPP-Assisted Intracellular Drug Delivery, What Is Next? |
title_fullStr |
CPP-Assisted Intracellular Drug Delivery, What Is Next? |
title_full_unstemmed |
CPP-Assisted Intracellular Drug Delivery, What Is Next? |
title_sort |
cpp-assisted intracellular drug delivery, what is next? |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-11-01 |
description |
For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and proteins into cells, thereby denying their clinical potential to become potent anti-cancer drugs. By taking the advantage of the unique cell-translocation property of these short peptides, various payloads of proteins, nucleic acids, or even nanoparticle-based carriers were delivered into all cell types with unparalleled efficiency. However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects. In view of these challenges, we present herein a review of the new designs of CPP-linked vehicles and strategies to achieve highly effective yet less toxic chemotherapy in combating tumor oncology. |
topic |
CPPs intracellular delivery pH and enzyme triggered drug delivery system |
url |
http://www.mdpi.com/1422-0067/17/11/1892 |
work_keys_str_mv |
AT junxiaoye cppassistedintracellulardrugdeliverywhatisnext AT ergangliu cppassistedintracellulardrugdeliverywhatisnext AT zhiliyu cppassistedintracellulardrugdeliverywhatisnext AT xingpei cppassistedintracellulardrugdeliverywhatisnext AT sunhuichen cppassistedintracellulardrugdeliverywhatisnext AT pengweizhang cppassistedintracellulardrugdeliverywhatisnext AT meongcheolshin cppassistedintracellulardrugdeliverywhatisnext AT junbogong cppassistedintracellulardrugdeliverywhatisnext AT huininghe cppassistedintracellulardrugdeliverywhatisnext AT victorcyang cppassistedintracellulardrugdeliverywhatisnext |
_version_ |
1725897684749910016 |