Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds

Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds

A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the mo...

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Main Authors: Kazuhito Tanabe, Takeo Ito, Sei-ichi Nishimoto
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.4061/2011/816207
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spelling doaj-369c2ae8bfbe4aacad9da89a794e1de12020-11-25T00:53:51ZengHindawi LimitedJournal of Nucleic Acids2090-021X2011-01-01201110.4061/2011/816207816207Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide BondsKazuhito Tanabe0Takeo Ito1Sei-ichi Nishimoto2Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, JapanDepartment of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, JapanDepartment of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, JapanA number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.http://dx.doi.org/10.4061/2011/816207
collection DOAJ
language English
format Article
sources DOAJ
author Kazuhito Tanabe
Takeo Ito
Sei-ichi Nishimoto
spellingShingle Kazuhito Tanabe
Takeo Ito
Sei-ichi Nishimoto
Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
Journal of Nucleic Acids
author_facet Kazuhito Tanabe
Takeo Ito
Sei-ichi Nishimoto
author_sort Kazuhito Tanabe
title Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_short Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_full Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_fullStr Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_full_unstemmed Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_sort radiolytic reduction characteristics of artificial oligodeoxynucleotides possessing 2-oxoalkyl group or disulfide bonds
publisher Hindawi Limited
series Journal of Nucleic Acids
issn 2090-021X
publishDate 2011-01-01
description A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.
url http://dx.doi.org/10.4061/2011/816207
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AT takeoito radiolyticreductioncharacteristicsofartificialoligodeoxynucleotidespossessing2oxoalkylgroupordisulfidebonds
AT seiichinishimoto radiolyticreductioncharacteristicsofartificialoligodeoxynucleotidespossessing2oxoalkylgroupordisulfidebonds
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