DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting...

Full description

Bibliographic Details
Main Authors:	Andrew E Teschendorff, Yang Gao, Allison Jones, Matthias Ruebner, Matthias W. Beckmann, David L. Wachter, Peter A. Fasching, Martin Widschwendter
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10478

id	doaj-36a2ba29445c4d0cb50f78cab96cf024
record_format	Article
spelling	doaj-36a2ba29445c4d0cb50f78cab96cf0242021-05-11T10:43:06ZengNature Publishing GroupNature Communications2041-17232016-01-017111210.1038/ncomms10478DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancerAndrew E Teschendorff0Yang Gao1Allison Jones2Matthias Ruebner3Matthias W. Beckmann4David L. Wachter5Peter A. Fasching6Martin Widschwendter7Department of Women’s Cancer, University College LondonCAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of SciencesDepartment of Women’s Cancer, University College LondonDepartment of Gynaecology and Obstetrics, University Clinic Erlangen, Friedrich-Alexander University Erlangen-NurembergDepartment of Gynaecology and Obstetrics, University Clinic Erlangen, Friedrich-Alexander University Erlangen-NurembergDepartment of Surgical Pathology, Institute of Pathology, University Clinic Erlangen, Friedrich-Alexander-University Erlangen-NurembergDepartment of Gynaecology and Obstetrics, University Clinic Erlangen, Friedrich-Alexander University Erlangen-NurembergDepartment of Women’s Cancer, University College LondonAltered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting that some of these events occur early in cancer.https://doi.org/10.1038/ncomms10478
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrew E Teschendorff Yang Gao Allison Jones Matthias Ruebner Matthias W. Beckmann David L. Wachter Peter A. Fasching Martin Widschwendter
spellingShingle	Andrew E Teschendorff Yang Gao Allison Jones Matthias Ruebner Matthias W. Beckmann David L. Wachter Peter A. Fasching Martin Widschwendter DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer Nature Communications
author_facet	Andrew E Teschendorff Yang Gao Allison Jones Matthias Ruebner Matthias W. Beckmann David L. Wachter Peter A. Fasching Martin Widschwendter
author_sort	Andrew E Teschendorff
title	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_short	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_full	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_fullStr	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_full_unstemmed	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_sort	dna methylation outliers in normal breast tissue identify field defects that are enriched in cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-01-01
description	Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting that some of these events occur early in cancer.
url	https://doi.org/10.1038/ncomms10478
work_keys_str_mv	AT andreweteschendorff dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT yanggao dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT allisonjones dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT matthiasruebner dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT matthiaswbeckmann dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT davidlwachter dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT peterafasching dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT martinwidschwendter dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer
_version_	1721447717171888128

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

Similar Items