Children's abnormalities associated with persistent thymic hyperplasia

• Main Author: Ya. V. Voropaeva
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2016-03-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; thymus; thymic hyperplasia; comorbidities.
• Online Access: https://www.ped-perinatology.ru/jour/article/view/285

Attention has been repeatedly drawn to the fact that persistent thymic hyperplasia (ICD-10 E32.0) is concurrent with morphological and/or functional disturbances of the nervous, endocrine, and immune systems, with various malformations and a number of other abnormalities in children. A retrospective controlled study was conducted through computer monitoring of the screenings of children of decreed ages. Children diagnosed with thymic enlargement have been found to have significantly more (functional and chronic) diseases and some conditions and nosological entities than the comparison group. All these abnormalities, as persistent thymic hyperplasia, are characterized by the presence of aggravating factors during ontogenesis. Thus, the association of persistent thymic hyperplasia with other abnormalities is due to the influence of similar factors, i.e. the fact that the increase in the volume and weight of the thymus above the limiting age values with maintenance of its normal histoarchitectonics arises from the joint action of genetic and environmental factors must not be ruled out.