miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity

Tumours produce soluble factors that contribute to the expansion of Gr-1+CD11b+ immature myeloid cells with TGFβ dependent immune suppressive function. Here, the authors show miR-130a and miR-145 target TβRII and reprogram these cells by altering the cytokine microenvironment, improving anti-tumour...

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Main Authors:	Hiroki Ishii, Suman K. Vodnala, Bhagelu R. Achyut, Jae Young So, M. Christine Hollander, Tim F. Greten, Ashish Lal, Li Yang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05023-9

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record_format	Article
spelling	doaj-36b455895b6a43af80a5ef29ba1eff982021-05-11T09:53:20ZengNature Publishing GroupNature Communications2041-17232018-07-019111510.1038/s41467-018-05023-9miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunityHiroki Ishii0Suman K. Vodnala1Bhagelu R. Achyut2Jae Young So3M. Christine Hollander4Tim F. Greten5Ashish Lal6Li Yang7Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIHLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIHLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIHLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIHLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIHGastrointestinal Malignancy Section, Center for Cancer Research, National Cancer Institute, NIHGenetic Branch, Center for Cancer Research, National Cancer Institute, NIHLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIHTumours produce soluble factors that contribute to the expansion of Gr-1+CD11b+ immature myeloid cells with TGFβ dependent immune suppressive function. Here, the authors show miR-130a and miR-145 target TβRII and reprogram these cells by altering the cytokine microenvironment, improving anti-tumour immunity and inhibiting metastasis in preclinical mouse models.https://doi.org/10.1038/s41467-018-05023-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hiroki Ishii Suman K. Vodnala Bhagelu R. Achyut Jae Young So M. Christine Hollander Tim F. Greten Ashish Lal Li Yang
spellingShingle	Hiroki Ishii Suman K. Vodnala Bhagelu R. Achyut Jae Young So M. Christine Hollander Tim F. Greten Ashish Lal Li Yang miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity Nature Communications
author_facet	Hiroki Ishii Suman K. Vodnala Bhagelu R. Achyut Jae Young So M. Christine Hollander Tim F. Greten Ashish Lal Li Yang
author_sort	Hiroki Ishii
title	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_short	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_full	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_fullStr	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_full_unstemmed	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_sort	mir-130a and mir-145 reprogram gr-1+cd11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	Tumours produce soluble factors that contribute to the expansion of Gr-1+CD11b+ immature myeloid cells with TGFβ dependent immune suppressive function. Here, the authors show miR-130a and miR-145 target TβRII and reprogram these cells by altering the cytokine microenvironment, improving anti-tumour immunity and inhibiting metastasis in preclinical mouse models.
url	https://doi.org/10.1038/s41467-018-05023-9
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miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity

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