Molecular Aspects of Plasmodium falciparum Infection during Pregnancy
Cytoadherence of Plasmodium-falciparum-parasitized red blood cells (PRBCs) to host receptors is the key phenomenon in the pathological process of the malaria disease. Some of these interactions can originate poor outcomes responsible for...
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Online Access: | http://dx.doi.org/10.1155/2007/43785 |
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doaj-36bf4c409aa9492e83db8de1ad88ee652020-11-25T00:16:04ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512007-01-01200710.1155/2007/4378543785Molecular Aspects of Plasmodium falciparum Infection during PregnancyNicaise Tuikue Ndam0Philippe Deloron1UR 010, Laboratoire de Parasitologie, Institut de Recherche pour le Développement, Université Paris Descartes, IFR 71, 4 avenue de l'Observatoire, Paris 75006, FranceUR 010, Laboratoire de Parasitologie, Institut de Recherche pour le Développement, Université Paris Descartes, IFR 71, 4 avenue de l'Observatoire, Paris 75006, FranceCytoadherence of Plasmodium-falciparum-parasitized red blood cells (PRBCs) to host receptors is the key phenomenon in the pathological process of the malaria disease. Some of these interactions can originate poor outcomes responsible for 1 to 3 million annual deaths mostly occurring among children in sub-Saharan Africa. Pregnancy-associated malaria (PAM) represents an important exception of the disease occurring at adulthood in malaria endemic settings. Consequences of this are shared between the mother (maternal anemia) and the baby (low birth weight and infant mortality). Demonstrating that parasites causing PAM express specific variant surface antigens (VSAPAM), including the P. falciparum erythrocyte membrane protein 1 (PfEMP1) variant VAR2CSA, that are targets for protective immunity has strengthened the possibility for the development of PAM-specific vaccine. In this paper, we review the molecular basis of malaria pathogenesis attributable to the erythrocyte stages of the parasites, and findings supporting potential anti-PAM vaccine components evidenced in PAM.http://dx.doi.org/10.1155/2007/43785 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicaise Tuikue Ndam Philippe Deloron |
spellingShingle |
Nicaise Tuikue Ndam Philippe Deloron Molecular Aspects of Plasmodium falciparum Infection during Pregnancy Journal of Biomedicine and Biotechnology |
author_facet |
Nicaise Tuikue Ndam Philippe Deloron |
author_sort |
Nicaise Tuikue Ndam |
title |
Molecular Aspects of Plasmodium falciparum Infection during Pregnancy |
title_short |
Molecular Aspects of Plasmodium falciparum Infection during Pregnancy |
title_full |
Molecular Aspects of Plasmodium falciparum Infection during Pregnancy |
title_fullStr |
Molecular Aspects of Plasmodium falciparum Infection during Pregnancy |
title_full_unstemmed |
Molecular Aspects of Plasmodium falciparum Infection during Pregnancy |
title_sort |
molecular aspects of plasmodium falciparum infection during pregnancy |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2007-01-01 |
description |
Cytoadherence of Plasmodium-falciparum-parasitized
red blood cells (PRBCs) to host receptors is the key phenomenon in
the pathological process of the malaria disease. Some of these interactions can
originate poor outcomes responsible for 1 to 3 million annual deaths mostly occurring
among children in sub-Saharan Africa. Pregnancy-associated malaria (PAM) represents
an important exception of the disease occurring at adulthood in malaria endemic
settings. Consequences of this are shared between the mother (maternal anemia) and
the baby (low birth weight and infant mortality). Demonstrating that parasites causing
PAM express specific variant surface antigens (VSAPAM), including the P. falciparum erythrocyte membrane
protein 1 (PfEMP1) variant VAR2CSA, that are targets for protective
immunity has strengthened the possibility for the development of PAM-specific
vaccine. In this paper, we review the molecular basis of malaria pathogenesis attributable
to the erythrocyte stages of the parasites, and findings supporting potential anti-PAM
vaccine components evidenced in PAM. |
url |
http://dx.doi.org/10.1155/2007/43785 |
work_keys_str_mv |
AT nicaisetuikuendam molecularaspectsofplasmodiumfalciparuminfectionduringpregnancy AT philippedeloron molecularaspectsofplasmodiumfalciparuminfectionduringpregnancy |
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