The Role of microRNAs in the Tumorigenesis of Ovarian Cancer
Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of women with EOC has changed little since platinum-base...
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doaj-36c32bc2954942b9ad6dc9e4c2922eb02020-11-25T03:10:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-06-01310.3389/fonc.2013.0015348380The Role of microRNAs in the Tumorigenesis of Ovarian CancerGianpiero Di Leva0Carlo M. Croce1Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State UniversityColumbus, OH, USADepartment of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State UniversityColumbus, OH, USAEpithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of women with EOC has changed little since platinum-based-treatment was introduced more than 30 years ago. Since 2006, an increasing number of studies have indicated an essential role for microRNAs (miRNAs) in ovarian-cancer tumorigenesis. Several miRNA profiling studies have shown that they associate with different aspects of ovarian cancer (tumor subtype, stage, histological grade, prognosis, and therapy resistance) and pointed to a critical role for miRNAs in the pathogenesis and progression of EOC. In this review, we discuss the current data concerning the accumulating evidence of the modulated expression of miRNAs in EOC, their role in diagnosis, prognosis, and prediction of response to therapy. Given the heterogeneity of this disease, it is likely that increases in long-term survival might be also achieved by translating the recent insights of miRNAs involvement in EOC into novel targeted therapies that will have a major impact on the management of ovarian cancer.https://www.frontiersin.org/article/10.3389/fonc.2013.00153/fullmicroRNAovarian cancernoncoding RNAmiRNA profilingmiRNA profiles |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gianpiero Di Leva Carlo M. Croce |
spellingShingle |
Gianpiero Di Leva Carlo M. Croce The Role of microRNAs in the Tumorigenesis of Ovarian Cancer Frontiers in Oncology microRNA ovarian cancer noncoding RNA miRNA profiling miRNA profiles |
author_facet |
Gianpiero Di Leva Carlo M. Croce |
author_sort |
Gianpiero Di Leva |
title |
The Role of microRNAs in the Tumorigenesis of Ovarian Cancer |
title_short |
The Role of microRNAs in the Tumorigenesis of Ovarian Cancer |
title_full |
The Role of microRNAs in the Tumorigenesis of Ovarian Cancer |
title_fullStr |
The Role of microRNAs in the Tumorigenesis of Ovarian Cancer |
title_full_unstemmed |
The Role of microRNAs in the Tumorigenesis of Ovarian Cancer |
title_sort |
role of micrornas in the tumorigenesis of ovarian cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2013-06-01 |
description |
Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of women with EOC has changed little since platinum-based-treatment was introduced more than 30 years ago. Since 2006, an increasing number of studies have indicated an essential role for microRNAs (miRNAs) in ovarian-cancer tumorigenesis. Several miRNA profiling studies have shown that they associate with different aspects of ovarian cancer (tumor subtype, stage, histological grade, prognosis, and therapy resistance) and pointed to a critical role for miRNAs in the pathogenesis and progression of EOC. In this review, we discuss the current data concerning the accumulating evidence of the modulated expression of miRNAs in EOC, their role in diagnosis, prognosis, and prediction of response to therapy. Given the heterogeneity of this disease, it is likely that increases in long-term survival might be also achieved by translating the recent insights of miRNAs involvement in EOC into novel targeted therapies that will have a major impact on the management of ovarian cancer. |
topic |
microRNA ovarian cancer noncoding RNA miRNA profiling miRNA profiles |
url |
https://www.frontiersin.org/article/10.3389/fonc.2013.00153/full |
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