Evaluation of Marine Diindolinonepyrane in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetic Properties in Beagle Dogs

Evaluation of Marine Diindolinonepyrane in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetic Properties in Beagle Dogs

A marine fibrinolytic compound was studied for use in thrombolytic therapy. Firstly, the absorption and transportation characteristics of 2,5-B<i>H</i>PA (2,5-B<i>H</i>PA:2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-tertahydro-6<i>H<...

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Bibliographic Details
Main Authors: Zibin Ma, Ruihua Guo, Jeevithan Elango, Bin Bao, Wenhui Wu
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Marine Drugs
Subjects:
fibrinolytic compound
caco-2 cell
apparent permeability coefficients (p<sub>app</sub>)
dogs
pharmacokinetics
Online Access:https://www.mdpi.com/1660-3397/17/12/651

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