Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era
Background: The human immunodeficiency virus (HIV) infection which manifests as acquired immunodeficiency syndrome (AIDS) is a disease involving the defects of the T-lymphocyte arm of the immune system. Certain laboratory parameters such as the cluster of differentiation (CD4) count and clinical par...
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doaj-36cc5352a24a481f8f7caefa10de2d5f2020-11-24T21:03:49ZengWolters Kluwer Medknow PublicationsContemporary Clinical Dentistry0976-237X0976-23612016-01-017453954310.4103/0976-237X.194122Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy eraSarat Kumar NayakBijay Kumar DasSurya Narayan DasNamita MohapatraSuryakanti NayakLipsa BhuyanBackground: The human immunodeficiency virus (HIV) infection which manifests as acquired immunodeficiency syndrome (AIDS) is a disease involving the defects of the T-lymphocyte arm of the immune system. Certain laboratory parameters such as the cluster of differentiation (CD4) count and clinical parameters have long been used as markers of disease progression. In industrialized countries, many studies show a highly correlation between the incidence of oral lesions and immunosuppression and hence, can be used as a marker of immunosuppression. This might not be applicable to a developing country like India. In this study, efforts have been made to supplement the present knowledge on various aspects of oral manifestations in HIV patients in the Indian subcontinent. Aims: To correlate the oral manifestations in HIV/AIDS patients to the level of circulating CD4+ T-lymphocyte count and their effect in anti-retroviral therapy (ART). Subjects and Methods: A total of 104 HIV positive patients were examined for oral lesions. The CD4 count estimated on the same day by fluorescent activated cell sort count machine was then correlated with various oral lesions. Results: Oral manifestations appeared when CD4 count decreased below 500 cells/mm3. Moreover, oral lesions found at different stages showed very strong correlation to their respective CD4 count. Furthermore, there was considerable decline in the incidence of oral manifestations in patients undergoing highly active ART. Conclusions: Oral manifestations are highly predictive markers of severe immune deterioration and disease progression in HIV patients.http://www.contempclindent.org/article.asp?issn=0976-237X;year=2016;volume=7;issue=4;spage=539;epage=543;aulast=NayakAcquired immunodeficiency syndromeantiretroviral therapycluster of differentiation 4human immunodeficiency virus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarat Kumar Nayak Bijay Kumar Das Surya Narayan Das Namita Mohapatra Suryakanti Nayak Lipsa Bhuyan |
spellingShingle |
Sarat Kumar Nayak Bijay Kumar Das Surya Narayan Das Namita Mohapatra Suryakanti Nayak Lipsa Bhuyan Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era Contemporary Clinical Dentistry Acquired immunodeficiency syndrome antiretroviral therapy cluster of differentiation 4 human immunodeficiency virus |
author_facet |
Sarat Kumar Nayak Bijay Kumar Das Surya Narayan Das Namita Mohapatra Suryakanti Nayak Lipsa Bhuyan |
author_sort |
Sarat Kumar Nayak |
title |
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era |
title_short |
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era |
title_full |
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era |
title_fullStr |
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era |
title_full_unstemmed |
Oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of North-East India in highly active antiretroviral therapy era |
title_sort |
oral manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome and their correlation to cluster of differentiation lymphocyte count in population of north-east india in highly active antiretroviral therapy era |
publisher |
Wolters Kluwer Medknow Publications |
series |
Contemporary Clinical Dentistry |
issn |
0976-237X 0976-2361 |
publishDate |
2016-01-01 |
description |
Background: The human immunodeficiency virus (HIV) infection which manifests as acquired immunodeficiency syndrome (AIDS) is a disease involving the defects of the T-lymphocyte arm of the immune system. Certain laboratory parameters such as the cluster of differentiation (CD4) count and clinical parameters have long been used as markers of disease progression. In industrialized countries, many studies show a highly correlation between the incidence of oral lesions and immunosuppression and hence, can be used as a marker of immunosuppression. This might not be applicable to a developing country like India. In this study, efforts have been made to supplement the present knowledge on various aspects of oral manifestations in HIV patients in the Indian subcontinent. Aims: To correlate the oral manifestations in HIV/AIDS patients to the level of circulating CD4+ T-lymphocyte count and their effect in anti-retroviral therapy (ART). Subjects and Methods: A total of 104 HIV positive patients were examined for oral lesions. The CD4 count estimated on the same day by fluorescent activated cell sort count machine was then correlated with various oral lesions. Results: Oral manifestations appeared when CD4 count decreased below 500 cells/mm3. Moreover, oral lesions found at different stages showed very strong correlation to their respective CD4 count. Furthermore, there was considerable decline in the incidence of oral manifestations in patients undergoing highly active ART. Conclusions: Oral manifestations are highly predictive markers of severe immune deterioration and disease progression in HIV patients. |
topic |
Acquired immunodeficiency syndrome antiretroviral therapy cluster of differentiation 4 human immunodeficiency virus |
url |
http://www.contempclindent.org/article.asp?issn=0976-237X;year=2016;volume=7;issue=4;spage=539;epage=543;aulast=Nayak |
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