Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine an...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19891-7 |
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doaj-36d6d32972464a4aafa1c9bc198444932021-05-11T08:33:42ZengNature Publishing GroupNature Communications2041-17232020-11-0111111710.1038/s41467-020-19891-7Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic miceFatai S. Oladunni0Jun-Gyu Park1Paula A. Pino2Olga Gonzalez3Anwari Akhter4Anna Allué-Guardia5Angélica Olmo-Fontánez6Shalini Gautam7Andreu Garcia-Vilanova8Chengjin Ye9Kevin Chiem10Colwyn Headley11Varun Dwivedi12Laura M. Parodi13Kendra J. Alfson14Hilary M. Staples15Alyssa Schami16Juan I. Garcia17Alison Whigham18Roy Neal Platt19Michal Gazi20Jesse Martinez21Colin Chuba22Stephanie Earley23Oscar H. Rodriguez24Stephanie Davis Mdaki25Katrina N. Kavelish26Renee Escalona27Cory R. A. Hallam28Corbett Christie29Jean L. Patterson30Tim J. C. Anderson31Ricardo Carrion32Edward J. Dick33Shannan Hall-Ursone34Larry S. Schlesinger35Xavier Alvarez36Deepak Kaushal37Luis D. Giavedoni38Joanne Turner39Luis Martinez-Sobrido40Jordi B. Torrelles41Texas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteTexas Biomedical Research InstituteHere, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine and therapeutic evaluation.https://doi.org/10.1038/s41467-020-19891-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fatai S. Oladunni Jun-Gyu Park Paula A. Pino Olga Gonzalez Anwari Akhter Anna Allué-Guardia Angélica Olmo-Fontánez Shalini Gautam Andreu Garcia-Vilanova Chengjin Ye Kevin Chiem Colwyn Headley Varun Dwivedi Laura M. Parodi Kendra J. Alfson Hilary M. Staples Alyssa Schami Juan I. Garcia Alison Whigham Roy Neal Platt Michal Gazi Jesse Martinez Colin Chuba Stephanie Earley Oscar H. Rodriguez Stephanie Davis Mdaki Katrina N. Kavelish Renee Escalona Cory R. A. Hallam Corbett Christie Jean L. Patterson Tim J. C. Anderson Ricardo Carrion Edward J. Dick Shannan Hall-Ursone Larry S. Schlesinger Xavier Alvarez Deepak Kaushal Luis D. Giavedoni Joanne Turner Luis Martinez-Sobrido Jordi B. Torrelles |
| spellingShingle |
Fatai S. Oladunni Jun-Gyu Park Paula A. Pino Olga Gonzalez Anwari Akhter Anna Allué-Guardia Angélica Olmo-Fontánez Shalini Gautam Andreu Garcia-Vilanova Chengjin Ye Kevin Chiem Colwyn Headley Varun Dwivedi Laura M. Parodi Kendra J. Alfson Hilary M. Staples Alyssa Schami Juan I. Garcia Alison Whigham Roy Neal Platt Michal Gazi Jesse Martinez Colin Chuba Stephanie Earley Oscar H. Rodriguez Stephanie Davis Mdaki Katrina N. Kavelish Renee Escalona Cory R. A. Hallam Corbett Christie Jean L. Patterson Tim J. C. Anderson Ricardo Carrion Edward J. Dick Shannan Hall-Ursone Larry S. Schlesinger Xavier Alvarez Deepak Kaushal Luis D. Giavedoni Joanne Turner Luis Martinez-Sobrido Jordi B. Torrelles Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice Nature Communications |
| author_facet |
Fatai S. Oladunni Jun-Gyu Park Paula A. Pino Olga Gonzalez Anwari Akhter Anna Allué-Guardia Angélica Olmo-Fontánez Shalini Gautam Andreu Garcia-Vilanova Chengjin Ye Kevin Chiem Colwyn Headley Varun Dwivedi Laura M. Parodi Kendra J. Alfson Hilary M. Staples Alyssa Schami Juan I. Garcia Alison Whigham Roy Neal Platt Michal Gazi Jesse Martinez Colin Chuba Stephanie Earley Oscar H. Rodriguez Stephanie Davis Mdaki Katrina N. Kavelish Renee Escalona Cory R. A. Hallam Corbett Christie Jean L. Patterson Tim J. C. Anderson Ricardo Carrion Edward J. Dick Shannan Hall-Ursone Larry S. Schlesinger Xavier Alvarez Deepak Kaushal Luis D. Giavedoni Joanne Turner Luis Martinez-Sobrido Jordi B. Torrelles |
| author_sort |
Fatai S. Oladunni |
| title |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_short |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_full |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_fullStr |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_full_unstemmed |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_sort |
lethality of sars-cov-2 infection in k18 human angiotensin-converting enzyme 2 transgenic mice |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-11-01 |
| description |
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine and therapeutic evaluation. |
| url |
https://doi.org/10.1038/s41467-020-19891-7 |
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