Pattern Recognition of Gene Expression with Singular Spectrum Analysis

• Main Authors: Hossein Hassani, Zara Ghodsi
• Format: Article
• Language: English
• Published: MDPI AG 2014-07-01
• Series: Medical Sciences
• Subjects: Drosophila melanogaster; segmentation; signal extraction; singular spectrum analysis
• Online Access: http://www.mdpi.com/2076-3271/2/3/127

Drosophila segmentation as a model organism is one of the most highly studied. Among many maternal segmentation coordinate genes, bicoid protein pattern plays a significant role during Drosophila embryogenesis, since this gradient determines most aspects of head and thorax development. Despite the fact that several models have been proposed to describe the bicoid gradient, due to its association with considerable error, each can only partially explain bicoid characteristics. In this paper, a modified version of singular spectrum analysis is examined for filtering and extracting the bicoid gene expression signal. The results with strong evidence indicate that the proposed technique is able to remove noise more effectively and can be considered as a promising method for filtering gene expression measurements for other applications.