Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review
Abstract Background Moraxella nonliquefaciens is a usually non-pathogenic biofilm-producing Gram-negative coccobacillus which may colonize the upper respiratory tract, rarely causing invasive disease. Although very rare, bloodstream infections caused by this organism have been described, showing oft...
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doaj-36df8bb07c644ced9fa5e1f97bf7645c2020-11-25T03:59:17ZengBMCBMC Infectious Diseases1471-23342019-10-011911510.1186/s12879-019-4489-yMoraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature reviewCarlos L. Correa-Martínez0Kerstin K. Rauwolf1Franziska Schuler2Miriam Füller3Stefanie Kampmeier4Andreas H. Groll5Institute of Hygiene, University Hospital MünsterDepartment of Pediatric Hematology and Oncology and Center for Bone Marrow Transplantation, University Children’s Hospital MünsterInstitute of Medical Microbiology, University Hospital MünsterDepartment of Pediatric Hematology and Oncology and Center for Bone Marrow Transplantation, University Children’s Hospital MünsterInstitute of Hygiene, University Hospital MünsterDepartment of Pediatric Hematology and Oncology and Center for Bone Marrow Transplantation, University Children’s Hospital MünsterAbstract Background Moraxella nonliquefaciens is a usually non-pathogenic biofilm-producing Gram-negative coccobacillus which may colonize the upper respiratory tract, rarely causing invasive disease. Although very rare, bloodstream infections caused by this organism have been described, showing often a fatal outcome. Here, we report the case of a pediatric cancer patient with bloodstream infection and sepsis due to M. nonliquefaciens showing full recovery after appropriate antibiotic treatment. Case presentation A three-year-old boy with stage IV neuroblastoma was admitted for high-dose chemotherapy with autologous stem cell rescue after standard neuroblastoma treatment. Despite receiving antimicrobial prophylaxis with trimethoprim/sulfamethoxazole, acyclovir and amphothericin B, the patient presented with fever of up to 39.5 °C and neutropenia. Besides a chemotherapy-related mucositis and an indwelling Broviac catheter (removed), no infection focus was identified on physical examination. Moraxella nonliquafaciens was identified in blood cultures. After antibiotic treatment and neutrophil recovery, the patient was fit for discharge. Conclusions The case described highlights the importance of an otherwise non-pathogenic microorganism, especially in immunosupressed cancer patients. It should be kept in mind that, although very infrequently, Moraxella nonliquefaciens may cause bloodstream infections that can be successfully treated with prompt focus identification and antibiotic therapy.http://link.springer.com/article/10.1186/s12879-019-4489-ySepsisMoraxella nonliquefaciensChildrenInfectionCancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos L. Correa-Martínez Kerstin K. Rauwolf Franziska Schuler Miriam Füller Stefanie Kampmeier Andreas H. Groll |
spellingShingle |
Carlos L. Correa-Martínez Kerstin K. Rauwolf Franziska Schuler Miriam Füller Stefanie Kampmeier Andreas H. Groll Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review BMC Infectious Diseases Sepsis Moraxella nonliquefaciens Children Infection Cancer |
author_facet |
Carlos L. Correa-Martínez Kerstin K. Rauwolf Franziska Schuler Miriam Füller Stefanie Kampmeier Andreas H. Groll |
author_sort |
Carlos L. Correa-Martínez |
title |
Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review |
title_short |
Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review |
title_full |
Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review |
title_fullStr |
Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review |
title_full_unstemmed |
Moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review |
title_sort |
moraxella nonliquefaciens bloodstream infection and sepsis in a pediatric cancer patient: case report and literature review |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2019-10-01 |
description |
Abstract Background Moraxella nonliquefaciens is a usually non-pathogenic biofilm-producing Gram-negative coccobacillus which may colonize the upper respiratory tract, rarely causing invasive disease. Although very rare, bloodstream infections caused by this organism have been described, showing often a fatal outcome. Here, we report the case of a pediatric cancer patient with bloodstream infection and sepsis due to M. nonliquefaciens showing full recovery after appropriate antibiotic treatment. Case presentation A three-year-old boy with stage IV neuroblastoma was admitted for high-dose chemotherapy with autologous stem cell rescue after standard neuroblastoma treatment. Despite receiving antimicrobial prophylaxis with trimethoprim/sulfamethoxazole, acyclovir and amphothericin B, the patient presented with fever of up to 39.5 °C and neutropenia. Besides a chemotherapy-related mucositis and an indwelling Broviac catheter (removed), no infection focus was identified on physical examination. Moraxella nonliquafaciens was identified in blood cultures. After antibiotic treatment and neutrophil recovery, the patient was fit for discharge. Conclusions The case described highlights the importance of an otherwise non-pathogenic microorganism, especially in immunosupressed cancer patients. It should be kept in mind that, although very infrequently, Moraxella nonliquefaciens may cause bloodstream infections that can be successfully treated with prompt focus identification and antibiotic therapy. |
topic |
Sepsis Moraxella nonliquefaciens Children Infection Cancer |
url |
http://link.springer.com/article/10.1186/s12879-019-4489-y |
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