Rebamipide using in gastroesophageal reflux disease treatment

Rebamipide using in gastroesophageal reflux disease treatment

Rebamipide is a mucoprotective drug which was developed in Japan in 1990. The therapeutic effect of rebamipide based on the induction of cyclooxygenase-2 and increasing level of prostaglandins, inhibition of oxygen free radicals production, epidermal growth factor stimulation, vascular endothelial g...

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Main Authors: V. T. Ivashkin, A. S. Trukhmanov, M. I. Gonik
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2020-04-01
Series:Терапевтический архив
Subjects:
rebamipide
gastroesophageal reflux disease
Online Access:https://ter-arkhiv.ru/0040-3660/article/viewFile/34115/22448
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spelling doaj-37160165ff014255aeb4fdbae066ca012021-01-26T09:27:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-04-019249810410.26442/00403660.2020.04.00056830755Rebamipide using in gastroesophageal reflux disease treatmentV. T. Ivashkin0A. S. Trukhmanov1M. I. Gonik2Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Rebamipide is a mucoprotective drug which was developed in Japan in 1990. The therapeutic effect of rebamipide based on the induction of cyclooxygenase-2 and increasing level of prostaglandins, inhibition of oxygen free radicals production, epidermal growth factor stimulation, vascular endothelial growth factor, nitric oxide, and decreasing of lipid peroxidation and neutrophils migration. The combination of proton pump inhibitors and rebamipide is more effective in relieving of gastroesophageal reflux disease symptoms and reducing recurrence rate of disease. Using rebamipide in the treatment of gastroesophageal reflux disease is justified because this drug has a unique mechanism of action, which eliminating the main stages of pathogenesis of the disease.https://ter-arkhiv.ru/0040-3660/article/viewFile/34115/22448rebamipidegastroesophageal reflux disease
collection DOAJ
language Russian
format Article
sources DOAJ
author V. T. Ivashkin
A. S. Trukhmanov
M. I. Gonik
spellingShingle V. T. Ivashkin
A. S. Trukhmanov
M. I. Gonik
Rebamipide using in gastroesophageal reflux disease treatment
Терапевтический архив
rebamipide
gastroesophageal reflux disease
author_facet V. T. Ivashkin
A. S. Trukhmanov
M. I. Gonik
author_sort V. T. Ivashkin
title Rebamipide using in gastroesophageal reflux disease treatment
title_short Rebamipide using in gastroesophageal reflux disease treatment
title_full Rebamipide using in gastroesophageal reflux disease treatment
title_fullStr Rebamipide using in gastroesophageal reflux disease treatment
title_full_unstemmed Rebamipide using in gastroesophageal reflux disease treatment
title_sort rebamipide using in gastroesophageal reflux disease treatment
publisher "Consilium Medicum" Publishing house
series Терапевтический архив
issn 0040-3660
2309-5342
publishDate 2020-04-01
description Rebamipide is a mucoprotective drug which was developed in Japan in 1990. The therapeutic effect of rebamipide based on the induction of cyclooxygenase-2 and increasing level of prostaglandins, inhibition of oxygen free radicals production, epidermal growth factor stimulation, vascular endothelial growth factor, nitric oxide, and decreasing of lipid peroxidation and neutrophils migration. The combination of proton pump inhibitors and rebamipide is more effective in relieving of gastroesophageal reflux disease symptoms and reducing recurrence rate of disease. Using rebamipide in the treatment of gastroesophageal reflux disease is justified because this drug has a unique mechanism of action, which eliminating the main stages of pathogenesis of the disease.
topic rebamipide
gastroesophageal reflux disease
url https://ter-arkhiv.ru/0040-3660/article/viewFile/34115/22448
work_keys_str_mv AT vtivashkin rebamipideusingingastroesophagealrefluxdiseasetreatment
AT astrukhmanov rebamipideusingingastroesophagealrefluxdiseasetreatment
AT migonik rebamipideusingingastroesophagealrefluxdiseasetreatment
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