Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110

Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR...

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Main Authors:	Zhen Fan, Zhang-Hua Sun, Zhong Liu, Yu-Chan Chen, Hong-Xin Liu, Hao-Hua Li, Wei-Min Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2016-09-01
Series:	Marine Drugs
Subjects:	diketopiperazines Dichotomomyces cejpii deep-sea-derived fungus cytotoxity α-glucosidase
Online Access:	http://www.mdpi.com/1660-3397/14/9/164

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spelling	doaj-372ec57c8dc34f58bb9f0c4553ab33862020-11-24T23:23:05ZengMDPI AGMarine Drugs1660-33972016-09-0114916410.3390/md14090164md14090164Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110Zhen Fan0Zhang-Hua Sun1Zhong Liu2Yu-Chan Chen3Hong-Xin Liu4Hao-Hua Li5Wei-Min Zhang6State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaGuangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, ChinaThree new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4–6, 10–11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, and SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity against α-glucosidase with an IC50 of 138 μM.http://www.mdpi.com/1660-3397/14/9/164diketopiperazinesDichotomomyces cejpiideep-sea-derived funguscytotoxityα-glucosidase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhen Fan Zhang-Hua Sun Zhong Liu Yu-Chan Chen Hong-Xin Liu Hao-Hua Li Wei-Min Zhang
spellingShingle	Zhen Fan Zhang-Hua Sun Zhong Liu Yu-Chan Chen Hong-Xin Liu Hao-Hua Li Wei-Min Zhang Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110 Marine Drugs diketopiperazines Dichotomomyces cejpii deep-sea-derived fungus cytotoxity α-glucosidase
author_facet	Zhen Fan Zhang-Hua Sun Zhong Liu Yu-Chan Chen Hong-Xin Liu Hao-Hua Li Wei-Min Zhang
author_sort	Zhen Fan
title	Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_short	Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_full	Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_fullStr	Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_full_unstemmed	Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_sort	dichotocejpins a–c: new diketopiperazines from a deep-sea-derived fungus dichotomomyces cejpii fs110
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2016-09-01
description	Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4–6, 10–11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, and SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity against α-glucosidase with an IC50 of 138 μM.
topic	diketopiperazines Dichotomomyces cejpii deep-sea-derived fungus cytotoxity α-glucosidase
url	http://www.mdpi.com/1660-3397/14/9/164
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Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110

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