The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model
Abstract Background Radiation-induced kidney damage can severely affect renal function, and have a serious impact on glucose reabsorption. Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely utilized for metabolic imaging of glucose utilization. In this study, we are trying to...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
|
Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12967-018-1626-0 |
id |
doaj-37325730e8414c859d660aa887087c33 |
---|---|
record_format |
Article |
spelling |
doaj-37325730e8414c859d660aa887087c332020-11-25T01:31:51ZengBMCJournal of Translational Medicine1479-58762018-09-0116111010.1186/s12967-018-1626-0The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs modelYu-Guang Tian0Min Yue1Bayaer Nashun2Shao-Jie Wu3Wei-Wang Gu4Yu-Jue Wang5Department of Laboratory Animal Center, Southern Medical UniversityDepartment of Laboratory Animal Center, Southern Medical UniversityDepartment of Guangdong Medical UniversityDepartment of Hemotology, Zhujiang Hospital, Southern Medical UniversityDepartment of Laboratory Animal Center, Southern Medical UniversityDepartment of Laboratory Animal Center, Southern Medical UniversityAbstract Background Radiation-induced kidney damage can severely affect renal function, and have a serious impact on glucose reabsorption. Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely utilized for metabolic imaging of glucose utilization. In this study, we are trying to assess the diagnostic value of 18F-FDG-PET/CT on measuring hyperacute effect of total body irradiation (TBI) on the kidneys. Methods Forty-eight Tibet minipigs were treated by TBI of different dosages using an 8-MV X-ray linear accelerator. Whole-body 18F-FDG-PET/CT was performed at 6, 24 and 72 h followed by histologic examination, blood samples’ and renal function analysis. Results The uptake of 18F-FDG was significantly different between 11/14 Gy dose groups and control group, the standard Uptake Values reached a maximal level at 72 h after 14-Gy TBI treatment. At doses over 8 Gy, histological observation showed formation of tube casts, degeneration, necrosis of tubular cells, inflammatory cell infiltration and dilatation of the mitochondria of tubule cells. Renal function analysis confirmed the changes in blood urea nitrogen and creatinine levels at various dosages and time intervals. Immunohistochemistry and western blot results indicate that the expression levels of IL-10 and TNF-α proteins were positively correlated with radiation dose up to 8 Gy. Conclusions 18F-FDG PET/CT can reflect pathological changes in kidneys and it may be a useful tool for rapid and non-invasive assessment in cases of suspected radiation-induced kidney damage.http://link.springer.com/article/10.1186/s12967-018-1626-018F-FDG PET/CTKidneyTotal body irradiationTibet minipigRadiation damageRapid assessment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Guang Tian Min Yue Bayaer Nashun Shao-Jie Wu Wei-Wang Gu Yu-Jue Wang |
spellingShingle |
Yu-Guang Tian Min Yue Bayaer Nashun Shao-Jie Wu Wei-Wang Gu Yu-Jue Wang The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model Journal of Translational Medicine 18F-FDG PET/CT Kidney Total body irradiation Tibet minipig Radiation damage Rapid assessment |
author_facet |
Yu-Guang Tian Min Yue Bayaer Nashun Shao-Jie Wu Wei-Wang Gu Yu-Jue Wang |
author_sort |
Yu-Guang Tian |
title |
The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model |
title_short |
The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model |
title_full |
The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model |
title_fullStr |
The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model |
title_full_unstemmed |
The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model |
title_sort |
diagnostic value of [18f]-fdg-pet/ct in assessment of radiation renal injury in tibet minipigs model |
publisher |
BMC |
series |
Journal of Translational Medicine |
issn |
1479-5876 |
publishDate |
2018-09-01 |
description |
Abstract Background Radiation-induced kidney damage can severely affect renal function, and have a serious impact on glucose reabsorption. Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely utilized for metabolic imaging of glucose utilization. In this study, we are trying to assess the diagnostic value of 18F-FDG-PET/CT on measuring hyperacute effect of total body irradiation (TBI) on the kidneys. Methods Forty-eight Tibet minipigs were treated by TBI of different dosages using an 8-MV X-ray linear accelerator. Whole-body 18F-FDG-PET/CT was performed at 6, 24 and 72 h followed by histologic examination, blood samples’ and renal function analysis. Results The uptake of 18F-FDG was significantly different between 11/14 Gy dose groups and control group, the standard Uptake Values reached a maximal level at 72 h after 14-Gy TBI treatment. At doses over 8 Gy, histological observation showed formation of tube casts, degeneration, necrosis of tubular cells, inflammatory cell infiltration and dilatation of the mitochondria of tubule cells. Renal function analysis confirmed the changes in blood urea nitrogen and creatinine levels at various dosages and time intervals. Immunohistochemistry and western blot results indicate that the expression levels of IL-10 and TNF-α proteins were positively correlated with radiation dose up to 8 Gy. Conclusions 18F-FDG PET/CT can reflect pathological changes in kidneys and it may be a useful tool for rapid and non-invasive assessment in cases of suspected radiation-induced kidney damage. |
topic |
18F-FDG PET/CT Kidney Total body irradiation Tibet minipig Radiation damage Rapid assessment |
url |
http://link.springer.com/article/10.1186/s12967-018-1626-0 |
work_keys_str_mv |
AT yuguangtian thediagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT minyue thediagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT bayaernashun thediagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT shaojiewu thediagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT weiwanggu thediagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT yujuewang thediagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT yuguangtian diagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT minyue diagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT bayaernashun diagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT shaojiewu diagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT weiwanggu diagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel AT yujuewang diagnosticvalueof18ffdgpetctinassessmentofradiationrenalinjuryintibetminipigsmodel |
_version_ |
1725084918301589504 |