Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery
Objective To estimate the effect of lorazepam in relieving postoperative wound pain and anxiety after spinal meningioma surgery. Methods A total of 106 patients underwent spinal meningioma resection with endotracheal general anesthesia. They were randomly divided into lorazepam group (N = 53) and c...
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Tianjin Huanhu Hospital
2017-12-01
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doaj-37448b827c954fc39073c2cfaf3beb8f2020-11-24T21:44:19ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312017-12-0117129249281669Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgeryYi-peng WANG0Wen-bin WANG1Department of Pain, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaObjective To estimate the effect of lorazepam in relieving postoperative wound pain and anxiety after spinal meningioma surgery. Methods A total of 106 patients underwent spinal meningioma resection with endotracheal general anesthesia. They were randomly divided into lorazepam group (N = 53) and control group (N = 53). Patients in lorazepam group were given lorazepam 0.50 mg one night before surgery and 6 h after surgery, while control group were given compound vitamin B at the same time. Operation time, intraoperative bleeding and wound healing after surgery were recorded. McCormick grade and Self-Rating Anxiety Scale (SAS) were used to evaluate the spinal function and anxiety. At 48 h after surgery, Visual Analogue Scale (VAS) was used to evaluate the degree of postoperative pain. Results All patients underwent tumor total resection, and spent the perioperative period safely. No complications such as infection happened. Neurological function were relieved to varying degrees and there was no worsening case. Compared with control group, SAS score in lorazepam group was significantly decreased at 48 h after surgery (P = 0.000). Compared with before surgery, SAS score in lorazepam group was significantly decreased at 48 h after surgery (P = 0.000). The VAS score at 48 h after surgery in lorazepam group was significantly lower than control group [(5.40 ± 1.24) score vs. (7.15 ± 1.12) score; t = 7.593, P = 0.000]. Conclusions Lorazepam as an antianxiety agent can effectively relieve postoperative pain after spinal meningioma resection. DOI: 10.3969/j.issn.1672-6731.2017.12.011http://www.cjcnn.org/index.php/cjcnn/article/view/1709LorazepamMeningeal neoplasmsPain, postoperativeAnxiety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-peng WANG Wen-bin WANG |
spellingShingle |
Yi-peng WANG Wen-bin WANG Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery Chinese Journal of Contemporary Neurology and Neurosurgery Lorazepam Meningeal neoplasms Pain, postoperative Anxiety |
author_facet |
Yi-peng WANG Wen-bin WANG |
author_sort |
Yi-peng WANG |
title |
Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery |
title_short |
Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery |
title_full |
Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery |
title_fullStr |
Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery |
title_full_unstemmed |
Clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery |
title_sort |
clinical study on lorazepam for treating postoperative pain of wound after spinal meningioma surgery |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2017-12-01 |
description |
Objective To estimate the effect of lorazepam in relieving postoperative wound pain and anxiety after spinal meningioma surgery. Methods A total of 106 patients underwent spinal meningioma resection with endotracheal general anesthesia. They were randomly divided into lorazepam group (N = 53) and control group (N = 53). Patients in lorazepam group were given lorazepam 0.50 mg one night before surgery and 6 h after surgery, while control group were given compound vitamin B at the same time. Operation time, intraoperative bleeding and wound healing after surgery were recorded. McCormick grade and Self-Rating Anxiety Scale (SAS) were used to evaluate the spinal function and anxiety. At 48 h after surgery, Visual Analogue Scale (VAS) was used to evaluate the degree of postoperative pain. Results All patients underwent tumor total resection, and spent the perioperative period safely. No complications such as infection happened. Neurological function were relieved to varying degrees and there was no worsening case. Compared with control group, SAS score in lorazepam group was significantly decreased at 48 h after surgery (P = 0.000). Compared with before surgery, SAS score in lorazepam group was significantly decreased at 48 h after surgery (P = 0.000). The VAS score at 48 h after surgery in lorazepam group was significantly lower than control group [(5.40 ± 1.24) score vs. (7.15 ± 1.12) score; t = 7.593, P = 0.000]. Conclusions Lorazepam as an antianxiety agent can effectively relieve postoperative pain after spinal meningioma resection.
DOI: 10.3969/j.issn.1672-6731.2017.12.011 |
topic |
Lorazepam Meningeal neoplasms Pain, postoperative Anxiety |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/1709 |
work_keys_str_mv |
AT yipengwang clinicalstudyonlorazepamfortreatingpostoperativepainofwoundafterspinalmeningiomasurgery AT wenbinwang clinicalstudyonlorazepamfortreatingpostoperativepainofwoundafterspinalmeningiomasurgery |
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