Inflammatory Marker but Not Adipokine Predicts Mortality among Long-Term Hemodialysis Patients
Aims: chronic inflammation contributes significantly to the morbidity and mortality of chronic hemodialysis patients. A recent research has shown that adipokines were associated with inflammation in these patients. We aim to investigate whether biomarkers of inflammation, adipokines, and...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2007-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/19891 |
| Summary: | Aims: chronic inflammation contributes significantly to the morbidity and
mortality of chronic hemodialysis patients. A recent research has shown that adipokines were associated
with inflammation in these patients. We aim to investigate whether biomarkers of inflammation, adipokines, and
clinical features can predict the outcome of hemodialysis patients. Materials and methods: we
enrolled 181 hemodialysis patients (men: 97, mean age: 56.3±13.6) and analyzed predictors of long-term outcomes. Results: during the 3-year
followup period, 41 patients died; the main causes of death were infection and cardiovascular disease. Elevated
serum levels of hsCRP and albumin and advanced age were highly associated with death
(all P<.001). Leptin and adiponectin levels were not significantly different between deceased patients
and survivors. Cox-regression analysis indicated that age, diabetes, albumin level, and hsCRP were independent
factors predicting mortality. Conclusion: the presence of underlying disease, advanced age, and
markers of chronic inflammation is strongly related to survival rate in long-term hemodialysis patients. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |