Anything Rare is Possible: Letrozole Induced Eczematous Skin Eruption
Letrozole is used as first line drug in postmenopausal women with early-stage or advanced hormone-sensitive breast cancer. Letrozole has favourable tolerability profile when administered once daily and significant adverse reactions occur rarely. The objective of this report is to describe a case o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4498/9028_F(DK)_PF1(P_S)_PFA(AK)_PF2(PAG)_PF2(PN_NC).pdf |
| Summary: | Letrozole is used as first line drug in postmenopausal women with early-stage or advanced hormone-sensitive breast cancer. Letrozole
has favourable tolerability profile when administered once daily and significant adverse reactions occur rarely. The objective of this report is
to describe a case of eczematous skin eruption that occurred during letrozole treatment. A 61-year-old female patient was admitted with
lump in the left breast. FNAC, HPE were done and the patient was diagnosed to have invasive ductal breast carcinoma. After a month of
completing CT and EBRT, the patient was given 2.5 mg OD tab. letrozole at night. She developed itchy skin lesions over the right thigh that
later generalised, at 6- weeks of treatment. The lesion has been defined as eczematous moderate to severe drug eruption. These lesions
were attributed to letrozole therapy and recurred within 24h after rechallenge. Drug eruption is associated with many drugs but this is the
first such report with letrozole. We suggest of being aware of such reactions during letrozole usage. |
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| ISSN: | 2249-782X 0973-709X |