Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance
PURPOSE: To analyze the immunohistochemical expression of the standard isoform of CD44 (CD44s) adhesion molecule in clear cell renal cell carcinoma (CCRCC) and its impact on clinical outcomes. MATERIALS AND METHODS: Ninety-nine consecutive patients treated surgically for RCC between 1992 and 2009 we...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Urologia
2012-08-01
|
Series: | International Brazilian Journal of Urology |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400004 |
id |
doaj-3756615223924aaab88465bcfb5483b6 |
---|---|
record_format |
Article |
spelling |
doaj-3756615223924aaab88465bcfb5483b62020-11-24T22:20:26ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192012-08-0138445646510.1590/S1677-55382012000400004Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significanceWalter Henriques da CostaRafael Malagoli RochaIsabela Werneck da CunhaGustavo Cardoso GuimaraesStenio de Cássio ZequiPURPOSE: To analyze the immunohistochemical expression of the standard isoform of CD44 (CD44s) adhesion molecule in clear cell renal cell carcinoma (CCRCC) and its impact on clinical outcomes. MATERIALS AND METHODS: Ninety-nine consecutive patients treated surgically for RCC between 1992 and 2009 were selected. A single pathologist reviewed all cases to effect a uniform reclassification and determine the most representative tumor areas for construction of a tissue microarray. The same pathologist, who was blinded to the outcome of the cases, semi-quantitatively scored the staining intensity of CD44s in all specimens. The counting was done using the H-Score algorithm. RESULTS: Of the 99 immunostained RCC specimens, 57(57.7%) showed low expression, and 42(42.4%) showed high expression levels of CD44s. The expression of CD44s was directly associated with tumor size (p = 0.03), clinical stage (p = 0.02) and Fuhrman grade (p = 0.02). Disease specific survival (DSS) rates for patients whose specimens expressed low and high levels of CD44s was 88.1% and 67.5%, respectively (p = 0.009). Progression free survival (PFS) rates in patients with low and high expression of CD44s were 78.8% and 61.7%, respectively (p = 0.05). Classical features such as the presence of metastasis and clinical stage remained isolated predictors of survival. CONCLUSIONS: Immunohistochemical expression of CD44s was associated with important clinical variables such as stage and Fuhrman grade. However, it was not an independent predictor of survival. Therefore, we believe it has a limited role as a prognostic marker in patients with CCRCC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400004Carcinoma, Renal CellAntigens, CD44Biological MarkersPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Walter Henriques da Costa Rafael Malagoli Rocha Isabela Werneck da Cunha Gustavo Cardoso Guimaraes Stenio de Cássio Zequi |
spellingShingle |
Walter Henriques da Costa Rafael Malagoli Rocha Isabela Werneck da Cunha Gustavo Cardoso Guimaraes Stenio de Cássio Zequi Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance International Brazilian Journal of Urology Carcinoma, Renal Cell Antigens, CD44 Biological Markers Prognosis |
author_facet |
Walter Henriques da Costa Rafael Malagoli Rocha Isabela Werneck da Cunha Gustavo Cardoso Guimaraes Stenio de Cássio Zequi |
author_sort |
Walter Henriques da Costa |
title |
Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance |
title_short |
Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance |
title_full |
Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance |
title_fullStr |
Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance |
title_full_unstemmed |
Immunohistochemical expression of CD44s in renal cell carcinoma lacks independent prognostic significance |
title_sort |
immunohistochemical expression of cd44s in renal cell carcinoma lacks independent prognostic significance |
publisher |
Sociedade Brasileira de Urologia |
series |
International Brazilian Journal of Urology |
issn |
1677-5538 1677-6119 |
publishDate |
2012-08-01 |
description |
PURPOSE: To analyze the immunohistochemical expression of the standard isoform of CD44 (CD44s) adhesion molecule in clear cell renal cell carcinoma (CCRCC) and its impact on clinical outcomes. MATERIALS AND METHODS: Ninety-nine consecutive patients treated surgically for RCC between 1992 and 2009 were selected. A single pathologist reviewed all cases to effect a uniform reclassification and determine the most representative tumor areas for construction of a tissue microarray. The same pathologist, who was blinded to the outcome of the cases, semi-quantitatively scored the staining intensity of CD44s in all specimens. The counting was done using the H-Score algorithm. RESULTS: Of the 99 immunostained RCC specimens, 57(57.7%) showed low expression, and 42(42.4%) showed high expression levels of CD44s. The expression of CD44s was directly associated with tumor size (p = 0.03), clinical stage (p = 0.02) and Fuhrman grade (p = 0.02). Disease specific survival (DSS) rates for patients whose specimens expressed low and high levels of CD44s was 88.1% and 67.5%, respectively (p = 0.009). Progression free survival (PFS) rates in patients with low and high expression of CD44s were 78.8% and 61.7%, respectively (p = 0.05). Classical features such as the presence of metastasis and clinical stage remained isolated predictors of survival. CONCLUSIONS: Immunohistochemical expression of CD44s was associated with important clinical variables such as stage and Fuhrman grade. However, it was not an independent predictor of survival. Therefore, we believe it has a limited role as a prognostic marker in patients with CCRCC. |
topic |
Carcinoma, Renal Cell Antigens, CD44 Biological Markers Prognosis |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400004 |
work_keys_str_mv |
AT walterhenriquesdacosta immunohistochemicalexpressionofcd44sinrenalcellcarcinomalacksindependentprognosticsignificance AT rafaelmalagolirocha immunohistochemicalexpressionofcd44sinrenalcellcarcinomalacksindependentprognosticsignificance AT isabelawerneckdacunha immunohistochemicalexpressionofcd44sinrenalcellcarcinomalacksindependentprognosticsignificance AT gustavocardosoguimaraes immunohistochemicalexpressionofcd44sinrenalcellcarcinomalacksindependentprognosticsignificance AT steniodecassiozequi immunohistochemicalexpressionofcd44sinrenalcellcarcinomalacksindependentprognosticsignificance |
_version_ |
1725775228694429696 |